MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.
MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.
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DOI：
10.1016/j.jim.2010.11.009
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发表时间：
2011-11-30
影响因子：
2.2
通讯作者：
Brusic, Vladimir
中科院分区：
文献类型：
--
作者：
Zhang, Guang Lan;DeLuca, David S.;Keskin, Derin B.;Chitkushev, Lou;Zlateva, Tanya;Lund, Ole;Reinherz, Ellis L.;Brusic, Vladimir
关键词：
MULTIPRED2是一个计算机系统，可以方便地预测与属于人类白细胞抗原(HLA)I类和II类DR分子的多个等位基因结合的多肽。它能够预测与单个等位基因、等位基因组合或人类白细胞抗原超型的产物结合的多肽。采用NetMHCpan型和NetMHCIIpan型作为预测引擎。13个人类白细胞抗原I类超型分别为A1、A2、A3、A24、B7、B8、B27、B44、B58、B62、C1和C4。13个人类白细胞抗原II类DR超型是DR1、DR3、DR4、DR6、DR7、DR8、DR9、DR11、DR12、DR13、DR14、DR15和DR16。总而言之，MULTIPRED2能够预测与代表26个HLA超类型的1077个变异体结合的多肽。MULTIPRED2具有可视化模块，用于绘制混杂的T细胞表位以及那些目标浓度较高的区域-称为T细胞表位热点。新的图形表示被用来以直观的方式显示预测的结合肽和免疫学热点，并以热图的形式提供结果的全局视图。与疫苗设计直接相关的MULTIPRED2的另一个功能是计算人口覆盖率。目前，它计算了北美五个主要群体的人口覆盖率。MULTIPRED2是对湿法实验室鉴定T细胞表位方法的重要补充。它在http://cvc.dfci.harvard.edu/multipred2/.上有售
MULTIPRED2 is a computational system for facile prediction of peptide binding to multiple alleles belonging to human leukocyte antigen (HLA) class I and class II DR molecules. It enables prediction of peptide binding to products of individual HLA alleles, combination of alleles, or HLA supertypes. NetMHCpan and NetMHCIIpan are used as prediction engines. The 13 HLA Class I supertypes are A1, A2, A3, A24, B7, B8, B27, B44, B58, B62, C1, and C4. The 13 HLA Class II DR supertypes are DR1, DR3, DR4, DR6, DR7, DR8, DR9, DR11, DR12, DR13, DR14, DR15, and DR16. In total, MULTIPRED2 enables prediction of peptide binding to 1077 variants representing 26 HLA supertypes. MULTIPRED2 has visualization modules for mapping promiscuous T-cell epitopes as well as those regions of high target concentration – referred to as T-cell epitope hotspots. Novel graphic representations are employed to display the predicted binding peptides and immunological hotspots in an intuitive manner and also to provide a global view of results as heat maps. Another function of MULTIPRED2, which has direct relevance to vaccine design, is the calculation of population coverage. Currently it calculates population coverage in five major groups in North America. MULTIPRED2 is an important tool to complement wet-lab experimental methods for identification of T-cell epitopes. It is available at http://cvc.dfci.harvard.edu/multipred2/.
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影响因子：
4.3
作者：
Nielsen M;Lundegaard C;Blicher T;Peters B;Sette A;Justesen S;Buus S;Lund O
通讯作者：
Lund O
影响因子：
3.7
作者：
Gupta V;Tabiin TM;Sun K;Chandrasekaran A;Anwar A;Yang K;Chikhlikar P;Salmon J;Brusic V;Marques ET;Kellathur SN;August TJ
通讯作者：
August TJ
影响因子：
3.7
作者：
Nielsen M;Lundegaard C;Blicher T;Lamberth K;Harndahl M;Justesen S;Røder G;Peters B;Sette A;Lund O;Buus S
通讯作者：
Buus S
影响因子：
4.4
作者：
Doytchinova, IA;Guan, PP;Flower, DR
通讯作者：
Flower, DR
DOI：
10.1073/pnas.79.14.4395
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MEUER, SC;SCHLOSSMAN, SF;REINHERZ, EL
通讯作者：
REINHERZ, EL