THE REGENERATION OF FINS AND FIN RAYS IN FUNDULUS HETEROCLITUS
THE REGENERATION OF FINS AND FIN RAYS IN FUNDULUS HETEROCLITUS
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DOI：
10.1002/jez.1401360306
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发表时间：
1957-01-01
影响因子：
--
通讯作者：
STAGG, MW
中科院分区：
文献类型：
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作者：
GOSS, RJ;STAGG, MW
异位叉鳍由截肢水平近端的结缔组织产生的未分化细胞的末端堆积而再生。通常排列在真皮鳍射线表面的成骨细胞也迁移到胚泡中，在那里它们负责产生再生的射线。骨沉积最初发生在表皮基底膜下方。失去神经的鳍，在没有再生的情况下，表现出有限的退化。从被截断的鳍上完全切除腹侧的鳍射线会导致相应的缺陷结构的再生。当在截肢节段后面短距离移除部分鳍射线时，光线再生通常从更近的节段开始。被移植到随后被截断的鳍片的径间区域的附加鳍条射线会导致在再生中形成相应的额外鳍条。因此，我们得出的结论是，射线再生只有在来自原有射线残端的成骨细胞的影响下才能形成。当鳍条的远端或中间部分从原本完整的鳍片上移除时，鳍条被从近端的鳍条残端向远端定向生长所取代。由于神经支配的中断，从远端残肢向近端方向的射线再生要么缺乏，要么相当迟缓。
The fins of Fundulus heteroclitus regenerate by the terminal accumulation of undifferentiated cells derived from the connective tissue immediately proximal to the level of amputation. Osteoblasts which normally line the surfaces of the dermal fin rays, also migrate into the blastema where they are responsible for giving rise to the regenerated rays. Bone deposition originally occurs immediately beneath the epidermal basement membrane. Denervated fins, in the absence of regeneration, exhibit limited regression. The complete extirpation of ventral halves of fin rays from amputated fins results in the regeneration of correspondingly deficient structures. When parts of fin rays are removed for short distances behind the level of amputation, ray regeneration proceeds normally from the more proximal level. Additional fin rays transplanted to the inter radial regions of subsequently amputated fins bring about the formation of corresponding extra rays in the regenerate. It is concluded, therefore, that ray regenerates are formed only under the influence of osteoblasts derived from pre-existing ray stumps. When distal or middle portions of fin rays are removed from otherwise intact fins, the rays are replaced by distally directed growth from the proximal ray stumps. Because of interrupted innervation, ray regeneration in a proximal direction from distal stumps is either lacking or considerably retarded.