Effects of magnetic field exposure on open field behaviour and nociceptive responses in mice
Effects of magnetic field exposure on open field behaviour and nociceptive responses in mice
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DOI：
10.1016/s0166-4328(03)00042-1
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发表时间：
2003-09-15
影响因子：
2.7
通讯作者：
Ghione, S
中科院分区：
文献类型：
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作者：
Del Seppia, C;Mezzasalma, L;Ghione, S
先前的研究结果表明，雄性C57小鼠的伤害感受敏感性通过暴露于规则的37 Hz或不规则变化（< 1 Hz）的电磁场而增强。为了测试这些磁场是否会更普遍地影响小鼠的行为，我们将Swiss CD-1小鼠置于一个新的环境中（旷场测试），并将其暴露于这两种不同的磁场条件下2小时。因此，我们分析了各种行为模式（即探索，后方，边缘咀嚼，自我梳理，坐，走和睡眠）的持续时间和时间过程以及伤害性敏感性受到这种暴露的影响。两个磁处理组（< 1 Hz，占总时间的33%和37 Hz，占总时间的29%）的探索活动总时间显著短于对照组（42%）。相反，治疗组的睡眠时间（均占总时间的27%）明显长于对照组（11%）。这些结果表明，暴露于改变的磁场诱导更快地适应新的环境。(C)2003 Elsevier Science B. V.保留所有权利。
Results of previous studies have shown that nociceptive sensitivity in male C57 mice is enhanced by exposure to a regular 37 Hz or an irregularly varying (< 1 Hz) electromagnetic field. In order to test whether these fields affect more generally mouse behaviour, we placed Swiss CD-1 mice in a novel environment (open field test) and exposed them for 2 h to these two different magnetic field conditions. Hence, we analysed how duration and time course of various behavioural patterns (i.e. exploration, rear, edge chew, self-groom, sit, walk and sleep) and nociceptive sensitivity had been affected by such exposure.Nociceptive sensitivity was significantly greater in magnetically treated mice than in controls. The overall time spent in exploratory activities was significantly shorter in both magnetically treated groups (< 1 Hz, 33% and 37 Hz, 29% of total time), than in controls (42%). Conversely, the time spent in sleeping was markedly longer in the treated groups (both 27% of total time) than in controls (11%). These results suggest that exposure to altered magnetic fields induce a more rapid habituation to a novel environment. (C) 2003 Elsevier Science B.V. All rights reserved.