Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia
Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia
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DOI：
10.1016/s0304-3835(02)00675-4
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发表时间：
2003-03-10
期刊：
影响因子：
9.7
通讯作者：
Kotsis, A
中科院分区：
文献类型：
--
作者：
Lambropoulos, AF;Agorastos, T;Kotsis, A
该研究的目的是探讨亚甲基四氢叶酸还原酶（MTHFR） C677T多态性与宫颈肿瘤之间的可能关联。共有229名妇女接受了细胞学和阴道镜检查。其中91人正常，作为对照组，其余138人目前或既往有组织学证实的宫颈病理（患者组）。对所有患者和对照组进行MTHFR C677T多态性调查。宫颈上皮内瘤变组和浸润性宫颈癌组与对照组的MTHFR C677T多态性发生频率差异无统计学意义。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
The aim of the study was to explore a possible association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cervical neoplasia. A total of 229 women were subjected to cytologic and colposcopic evaluation. Ninety-one of them were found to be normal, and served as the control group, while the other 138 of them had present or past histologically proven cervical pathology (patients group). All patients and controls were investigated for the MTHFR C677T polymorphism. Statistical analysis between the groups of cases with cervical intraepithelial neoplasia or invasive cervical cancer and the control group did not reveal any statistically significant difference in the frequency of the MTHFR C677T polymorphism. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.