Overview article: biostructure of blood platelets.
Overview article: biostructure of blood platelets.
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DOI：
10.3109/01913128009140561
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发表时间：
1980-10
影响因子：
1
通讯作者：
James G. White;C. Clawson
中科院分区：
文献类型：
--
作者：
James G. White;C. Clawson
生物化学、生理学、免疫学和细胞化学的进步，结合各种新的精细结构评价方法，对血小板的结构生理学和病理学有了新的认识。血小板颗粒亚群已被明确界定；它们包括含有过氧化氢酶的细胞器，称为过氧化物酶体；包裹水解酶的溶酶体；以及含有血小板因子4、有丝分裂因子、β血栓球蛋白、凝血酶敏感蛋白、纤维蛋白原和凝血因子V的α -颗粒。血小板膜系统的特征已经被很好地描述，最近的证据表明，膜复合物作为血小板的肌浆网和前列腺素合成的部位。通过这些观察，对血小板生物结构的理解得到了提高，从而有可能在体外和体内建立结构缺陷与细胞病理行为之间的特定关系。
Advances in biochemistry, physiology, immunology, and cytochemistry, combined with a variety of new approaches for the evaluation of fine structure, have yielded new insights into the structural physiology and pathology of blood platelets. Subpopulations of platelet granules have been clearly defined; they include the catalase containing organelles referred to as peroxisomes; lysosomes enclosing hydrolytic enzymes; and the alpha-granules in which platelet factor 4, mitogenic factor, beta thromboglobulin, thrombin sensitive protein, fibrinogen, and coagulation factor V are localized. Features of platelet membrane systems have been particularly well-delineated, and recent evidence suggests that membrane complexes serve as the sarcoplasmic reticulum of platelets and the site of prostaglandin synthesis. Improved understanding of platelet biostructure resulting from these observations has made it possible to develop specific relationships between defects in structure and pathological behavior of the cells in vitro and in vivo.