Pain-related aversion and Fos expression in the central nervous system in rats
Pain-related aversion and Fos expression in the central nervous system in rats
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DOI：
10.1097/00001756-200401190-00014
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发表时间：
2004-01-19
期刊：
影响因子：
1.7
通讯作者：
Zhao, ZQ
中科院分区：
文献类型：
--
作者：
Lei, LG;Zhang, YQ;Zhao, ZQ
与痛感相比，慢性疼痛患者遭受的情感情绪障碍要多得多。本研究采用福尔马林诱导的条件性位置回避(F-CPA)实验，研究了Fos在大鼠痛觉厌恶中的表达。当提取疼痛体验时，F-CPA组大鼠产生了严格的情绪样行为。结果发现，在扣带回前皮质、脾后皮质、岛叶皮质、顶叶皮质2区、额叶皮质1~3区、屏蔽区、外侧隔区、杏仁核、下丘脑背内侧核、中央内侧核、室旁核、上丘、下丘和中脑导水管周围灰质有较多的Fos-L1神经元。这一结果首次绘制了大鼠大脑中与疼痛、情感和情绪处理相关的区域。
Patients with chronic pain suffer from much more affective emotional disturbance than pain sensation. The present study examined Fos expression associated with pain-related aversion in rats, using formalin-induced conditioned place avoidance (F-CPA) test, which could distinguish pain emotion from pain sensation. When pain experience was retrieved, the rats with F-CPA produced rigorous emotion-like behaviors. As a result, more Fos-Ll neurons were observed in anterior cingulate cortex, retrosplenial cortex, insular cortex, parietal cortex area 2, frontal cortex area 1-3, claustrum, lateral septal area, amygdala, dorsomedial hypothalamic nucleus, central medial nucleus, paraventricular nucleus, superior colliculus, inferior colliculus and periaqueductal gray. The results for the first time mapped the brain regions associated with processing of pain affect and emotion in rats.