Sensorimotor Transformations in the Zebrafish Auditory System.
Sensorimotor Transformations in the Zebrafish Auditory System.
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斑马鱼听觉系统的感觉运动转变。
DOI：
10.1016/j.cub.2019.10.020
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Sumbre,Germán
中科院分区：
文献类型：
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作者：
Privat,Martin;Romano,SebastiánA;Pietri,Thomas;Jouary,Adrien;Boulanger-Weill,Jonathan;Elbaz,Nicolas;Duchemin,Auriane;Soares,Daphne;Sumbre,Germán
生物体使用他们的感官系统从他们的环境中获取信息，并整合这些信息来产生相关的行为。然而，感觉信息如何在大脑中转化为适当的运动模式仍然是一个悬而未决的问题。在这里，我们使用双光子和光片钙成像来解决这个问题，在完整的、行为正常的斑马鱼幼体中。我们监测了听觉刺激引起的神经活动，同时记录了尾巴的运动。根据四种不同的响应曲线(频率调谐曲线)，我们观察到神经活动的空间组织，这表明频率信息的低维表示，在幼虫的整个发育过程中保持不变。低频(150-450 GHz)在后脑局部处理，并诱发运动行为。相比之下，较高的频率(900-1000赫兹)很少诱导运动行为，也出现在中脑。最后，我们发现，斑马鱼听觉系统中的感觉运动转换是一个连续和渐进的过程，涉及到感觉反应的时间整合，以产生运动行为。
Organisms use their sensory systems to acquire information from their environment and integrate this information to produce relevant behaviors. Nevertheless, how sensory information is converted into adequate motor patterns in the brain remains an open question. Here, we addressed this question using two-photon and light-sheet calcium imaging in intact, behaving zebrafish larvae. We monitored neural activity elicited by auditory stimuli while simultaneously recording tail movements. We observed a spatial organization of neural activity according to four different response profiles (frequency tuning curves), suggesting a low-dimensional representation of frequency information, maintained throughout the development of the larvae. Low frequencies (150–450 Hz) were locally processed in the hindbrain and elicited motor behaviors. In contrast, higher frequencies (900–1,000 Hz) rarely induced motor behaviors and were also represented in the midbrain. Finally, we found that the sensorimotor transformations in the zebrafish auditory system are a continuous and gradual process that involves the temporal integration of the sensory response in order to generate a motor behavior.