Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection
Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection
复制标题
DOI：
10.1021/acsnano.7b04318
复制
发表时间：
2017-10-01
期刊：
影响因子：
17.1
通讯作者：
Lee, Hakho
中科院分区：
文献类型：
--
作者：
Lin, Hsing-Ying;Huang, Chen-Han;Lee, Hakho
不良食物反应，包括食物过敏、食物敏感和自身免疫反应（例如，乳糜泻）影响5-15%的人口，并且仍然是相当大的公共卫生问题，需要严格的食物避免和肾上腺素的可用性以用于紧急事件。鉴于目前人们对预制食品和外出就餐的依赖，避免食用有问题的食品实际上是困难的。作为回应，我们开发了一种便携式的使用点检测技术，称为集成外源性抗原检测（iEAT）。该系统由一个一次性抗原提取装置和一个电子钥匙链读取器组成，用于快速传感和通信。我们优化了原型TEAT系统，以检测花生，榛子，小麦，牛奶和鸡蛋中的五种主要食物抗原。抗原提取和iEAT检测需要
Adverse food reactions, including food allergies, food sensitivities, and autoimmune reaction (e.g., celiac disease) affect 5-15% of the population and remain a considerable public health problem requiring stringent food avoidance and epinephrine availability for emergency events. Avoiding problematic foods is practically difficult, given current reliance on prepared foods and out-of-home meals. In response, we developed a portable, point-of use detection technology, termed integrated exogenous antigen testing (iEAT). The system consists of a disposable antigen extraction device coupled with an electronic keychain reader for rapid sensing and communication. We optimized the prototype TEAT system to detect five major food antigens in peanuts, hazelnuts, wheat, milk, and eggs. Antigen extraction and detection with iEAT requires