Change of acute hepatitis B transmission routes in Japan
Change of acute hepatitis B transmission routes in Japan
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日本急性乙型肝炎传播途径的变化
DOI：
10.1007/s00535-003-1144-5
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发表时间：
2003
影响因子：
6.3
通讯作者：
M. Onji
中科院分区：
文献类型：
--
作者：
S. Arima;K. Michitaka;N. Horiike;K. Kawai;H. Matsubara;Seiji Nakanishi;M. Abe;A. Hasebe;Yoshio Tokumoto;Kazuhisa Yamamoto;M. Onji
背景。自从开始实施各种预防乙型肝炎病毒（HBV）传播的预防政策以来，已经过去了许多年。我们研究了过去27年来急性乙型肝炎患者乙型肝炎病毒感染途径的时间变化。方法。本研究纳入了 1976 年至 2002 年期间入住我院的 72 例急性 HBV 感染患者。本研究分为两个阶段（第一阶段，1976-1990年；第二阶段，1991-2002年），对HBV感染途径进行研究。结果。感染途径一直在改变。输血后肝炎仅见于第一期。第二阶段，性传播是主要的感染途径（68%），其次是医疗机构感染或针刺伤等职业暴露（8%）。结论。性接触传播已成为日本乙肝病毒的主要传染途径。
Background. Many years have passed since various prophylactic policies for preventing hepatitis B virus (HBV) transmission were begun. We studied the chronological alterations in HBV infectious routes in patients with acute hepatitis B in the past 27 years. Methods. Seventy-two patients with acute HBV infection who were admitted to our hospital during the period 1976 to 2002 were enrolled in this study. This study was divided into two periods (first period, 1976–1990; and second period, 1991–2002), and the HBV infectious routes were studied. Results. Infectious routes have been changing. Posttransfusion hepatitis was seen only in the first period. In the second period, sexual transmission was the major infectious route (68%), followed by infection at a medical facility or occupational exposure such as needlestick injury (8%). Conclusions. Transmission from sexual contact has become the main infectious route of HBV in Japan.