The course of untreated seizures in the pilocarpine model of epilepsy
The course of untreated seizures in the pilocarpine model of epilepsy
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DOI：
10.1016/s0920-1211(98)00092-8
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发表时间：
1999-04-01
影响因子：
2.2
通讯作者：
Cavalheiro, EA
中科院分区：
文献类型：
--
作者：
Arida, RM;Scorza, FA;Cavalheiro, EA
未经治疗的癫痫病程并不好。已确立的。本研究使用慢性边缘癫痫模型（毛果芸香碱癫痫模型）来确定未经治疗的动物癫痫发作的模式。给予毛果芸香碱后，在第一次自发性癫痫发作后 135 天，用视频系统连续监测 21 只大鼠。动物的癫痫发作次数存在很大差异，并被分为两个亚组，即癫痫发作频率较低（n = 9只动物在观察的前15天内出现10次或更少的癫痫发作）或癫痫发作频率较高（n = 12只动物在此期间出现超过10次癫痫发作）。在观察的前 15 天中癫痫发作次数较少的动物在接下来的分析期间（直到 105 天）表现出癫痫发作频率显着增加。另一方面，那些最初癫痫发作次数较多的患者仅在前 2 个月内出现癫痫发作频率的显着变化。每次自发性癫痫发作的持续时间并没有随时间发生显着变化。这些发现表明，未经治疗的癫痫在早期有一个成熟过程，这种加速过程对癫痫的治疗具有预测价值。 (C) 1999 Elsevier Science B.V. 保留所有权利。
The course of untreated epilepsy is not well. established. This study uses a model of chronic limbic epilepsy (pilocarpine model of epilepsy) to determine the pattern of occurrence of seizures in untreated animals. Following pilocarpine administration, 21 rats were monitored continuously with a video system for 135 days after the first spontaneous seizure. Animals showed a great variability in seizure numbers and were divided in two subgroups presenting either a low frequency of seizures (n = 9 animals presenting ten or less seizures in the first 15 days of observation) or a high frequency of seizures (n = 12 animals presenting more than ten seizures during this period). Animals with low number of seizures during the first 15 days of observation showed a significant increase in seizure frequency in the following period of analysis (until 105 days). On the other hand, those with initial high number of seizures showed Significant changes in seizure frequency only in the first 2 months. The duration of each spontaneous seizure did not change significantly over time. These findings show that in untreated epilepsy there is a maturation process in the early stages and this accelerating process can be of predictive value for the treatment of epilepsy. (C) 1999 Elsevier Science B.V. All rights reserved.