Cancer Stem Cells in Solid Tumors: An Overview
Cancer Stem Cells in Solid Tumors: An Overview
复制标题
DOI：
10.1016/j.semradonc.2008.11.001
复制
发表时间：
2009-04-01
影响因子：
3.5
通讯作者：
Dick, John E.
中科院分区：
文献类型：
--
作者：
O'Brien, Catherine Adell;Kreso, Antonija;Dick, John E.
长期以来，人们已经认识到，在构成肿瘤的单个细胞内可能存在显著的功能和形态异质性。越来越多的证据表明，许多实体瘤以分层方式组织，其中肿瘤生长由癌症干细胞（CSC）或肿瘤起始细胞的小子集驱动。虽然这些细胞占整个肿瘤群体的一小部分，但它们是唯一能够启动和驱动肿瘤生长的细胞。新出现的证据表明，这些细胞对化疗和放疗也有抗性，这导致了围绕CSC潜在临床应用的许多猜测和兴趣。Semin Radiat Oncol 19：71-77（C）2009 Elsevier Inc. All rights reserved.
It has long been appreciated that significant functional and morphologic heterogeneity can exist within the individual cells that comprise a tumor. Increasing evidence indicates that many solid tumors are organized in a hierarchical manner in which tumor growth is driven by a small subset of cancer stem cells (CSCs) or tumor-initiating cells. Although these cells represent a small percentage of the overall tumor population, they are the only cells capable of initiating and driving tumor growth. Emerging evidence indicates that these cells are also resistant to chemotherapy and radiation therapy, which has led to much speculation and interest surrounding the potential clinical applicability of CSCs. Semin Radiat Oncol 19:71-77 (C) 2009 Elsevier Inc. All rights reserved.