Regulation of mammalian pre-mRNA splicing
Regulation of mammalian pre-mRNA splicing
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DOI：
10.1007/s11427-009-0037-0
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发表时间：
2009-03-01
期刊：
影响因子：
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通讯作者：
Hui JingYi
中科院分区：
文献类型：
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作者：
Hui JingYi
在真核生物中，大多数蛋白质编码基因含有内含子，内含子通过前体信使RNA （pre-mRNA）剪接去除。选择性剪接是由单个前mrna产生多个信使rna (mrna)，从而产生功能不同的蛋白质的过程。最近对选择性剪接的全基因组分析表明，在高等真核生物中，选择性剪接是产生蛋白质组复杂性和调节基因表达的重要机制。剪接的错误调控导致了广泛的人类疾病。本文综述了目前对前体mrna剪接的理解以及调控哺乳动物前体mrna剪接的机制。讨论了选择性剪接领域的新方向。
In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins. Recent genome-wide analyses of alternative splicing indicated that in higher eukaryotes alternative splicing is an important mechanism that generates proteomic complexity and regulates gene expression. Mis-regulation of splicing causes a wide range of human diseases. This review describes the current understanding of pre-mRNA splicing and the mechanisms that regulate mammalian pre-mRNA splicing. It also discusses emerging directions in the field of alternative splicing.