Local allergic rhinitis to Alternaria alternata. Evidence for local IgE production exclusively in the nasal mucosa
Local allergic rhinitis to Alternaria alternata. Evidence for local IgE production exclusively in the nasal mucosa
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DOI：
10.1007/s00106-015-0005-x
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发表时间：
2015-05-01
期刊：
影响因子：
0.9
通讯作者：
Pfaar, O.
中科院分区：
文献类型：
--
作者：
Klimek, L.;Bardenhewer, C.;Pfaar, O.
在有过敏性鼻炎（AR）症状的患者亚组中，皮肤试验或血清中未检测到全身致敏反应。这些患者被认为患有所谓的“局部变应性鼻炎”（LAR），IgE仅在鼻粘膜部位产生。过敏试验阴性但有季节性（间歇性）或常年性（持续性）过敏症状的患者过去常被误诊为“非过敏性鼻炎”（NAR），但有证据表明这些患者的鼻粘膜中有特异性IgE产生，而无全身致敏反应。LAR的诊断是通过临床症状，特异性IgE的检测，在鼻粘膜和/或鼻腔激发tests.We报告的两例LAR互隔交链孢菌的症状持续性过敏性鼻炎已被诊断为阳性过敏原特异性鼻腔激发试验和特异性IgE测定鼻分泌物。根据实际文献调查，这是第二篇关于链格孢菌引起的LAR的报道。
In a subgroup of patients with symptoms of allergic rhinitis (AR), no systemic sensitization can be detected in skin tests or serum. These patients are considered to be afflicted with so-called "local allergic rhinitis" (LAR) with IgE-production exclusively at the site of the nasal mucosa. Patients without any positive allergy test results but seasonal (intermittent) or perennial (persistent) allergic symptoms were often misdiagnosed as having "non-allergic rhinitis" (NAR) in the past.However, there is evidence for a specific IgE-production in the nasal mucosa in these patients without systemic sensitization. The diagnosis of LAR is confirmed by clinical symptoms, the detection of specific IgE production in the nasal mucosa and/or nasal provocation tests.We report on two cases of LAR to Alternaria alternata with symptoms of persistent allergic rhinitis that have been diagnosed by positive allergenspecific nasal challenge tests and specific IgE determinations in nasal secretions. According to an actual literature research, this is the second report published on LAR caused by Alternaria alternata.