Changes in bronchial inflammation during acute exacerbations of chronic bronchitis
Changes in bronchial inflammation during acute exacerbations of chronic bronchitis
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DOI：
10.1183/09031936.01.99114901
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发表时间：
2001-06-01
影响因子：
24.3
通讯作者：
Stockley, RA
中科院分区：
文献类型：
--
作者：
Gompertz, S;O'Brien, C;Stockley, RA
描述慢性支气管炎恶化期间支气管炎症非细胞变化的数据很少，已评估了慢性支气管炎恶化期间和慢性阻塞性肺病初级保健诊断患者的痰颜色与就诊时气道炎症之间的关系。痰髓过氧化物酶、中性粒细胞弹性蛋白酶、白三烯 B-4 (LTB4)、白介素-8 (IL-8)、溶胶：血清对出现病情加重且有粘液样痰 (n = 27) 或脓痰 (n = 42) 的患者测量白蛋白比率和血清 C 反应蛋白。粘液样加重与就诊时的少量支气管或全身炎症相关，痰细菌学与稳定状态下获得的痰细菌学相似。化脓性加重与明显的支气管和全身炎症（所有特征p<0.025）和痰培养阳性（90%）相关。分辨率与 LTB4 的显着减少有关 (p
There are little data describing noncellular changes in bronchial inflammation during exacerbations of chronic bronchitis, The relationship between sputum colour and airway inflammation at presentation has been assessed during an exacerbation in patients with chronic bronchitis and a primary care diagnosis of chronic obstructive pulmonary disease.Sputum myeloperoxidase, neutrophil elastase, leukotriene B-4 (LTB4), interleukin-8 (IL-8), sol:serum albumin ratio and serum C-reactive protein were measured in patients presenting with an exacerbation and mucoid (n = 27) or purulent sputum (n = 42).Mucoid exacerbations were associated with little bronchial or systemic inflammation at presentation, and sputum bacteriology was similar to that obtained in the stable state. Purulent exacerbations were associated with marked bronchial and systemic inflammation (p < 0.025 for all features) and positive sputum cultures (90%). Resolution was related to a significant reduction in LTB4 (p