Plasma vitamin D biomarkers and leukocyte telomere length in men
Plasma vitamin D biomarkers and leukocyte telomere length in men
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DOI：
10.1007/s00394-015-1095-7
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发表时间：
2017-03-01
影响因子：
5
通讯作者：
De Vivo, Immaculata
中科院分区：
文献类型：
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作者：
Julin, Bettina;Shui, Irene M.;De Vivo, Immaculata
维生素D可能通过抗炎和抗细胞增殖机制减少端粒缩短。在女性中，较高的血浆25-羟基维生素D （25(OH)D）已被证明与较长的端粒长度有关，但在男性中尚未对这种关系进行评估。我们对2483名男性进行了25(OH)D, 1,25-二羟基维生素D (1,25（OH)(2)D）和相对白细胞端粒长度（LTL）的横断面分析[1832名男性为1,25(OH)(2)D]，他们被选为健康专业人员随访研究中三个端粒和癌症研究的病例和对照。我们还对代表维生素D途径基因常见遗传变异的95个snp进行了基因分型。采用定量PCR法测定LTL，并计算各研究的z分数。通过调整年龄和其他潜在混杂因素的线性和逻辑回归来评估相关性。年龄（P-trend < 0.0001）、吸烟包年（P-trend = 0.04）和体重指数（P-trend = 0.05）与LTL呈负相关。25(OH)D和1,25(OH)(2)D均与LTL无关（线性回归模型的多变量调整p趋势分别为0.69和0.41）。类视黄醇X受体α基因的一个SNP与长LTL相关（P = 0.0003）。在这项男性横断面研究中，25(OH) D和125 (OH)(2)D与相对LTL无关。
Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In women, higher plasma 25-hydroxyvitamin D (25(OH)D) has been shown to be associated with longer telomere length, but the relationship has not been assessed in men.We conducted a cross-sectional analysis of 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and relative leukocyte telomere length (LTL) among 2483 men [1832 men for 1,25(OH)(2)D] who were selected as cases and controls in three studies of telomeres and cancer nested within the Health Professionals Follow-up Study. We also genotyped 95 SNPs representing common genetic variation in vitamin D pathway genes. LTL was measured by quantitative PCR, and z-scores within each study were calculated. Associations were assessed by linear as well as logistic regression adjusting for age and other potential confounders.Age (P-trend < 0.0001), pack-years of smoking (P-trend = 0.04) and body mass index (P-trend = 0.05) were inversely associated with LTL. Neither 25(OH)D nor 1,25(OH)(2)D was associated with LTL (multivariable-adjusted P-trend 0.69 and 0.41, respectively, for the linear regression model). One SNP in the retinoid X receptor alpha gene was associated with long LTL (P = 0.0003).In this cross-sectional study of men, 25(OH)D and 1,25(OH)(2)D were not associated with relative LTL.