Sonodynamic cancer therapy: a non-invasive and repeatable approach using low-intensity ultrasound with a sonosensitizer.
Sonodynamic cancer therapy: a non-invasive and repeatable approach using low-intensity ultrasound with a sonosensitizer.
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发表时间：
2011-07
影响因子：
2
通讯作者：
H. Shibaguchi;H. Tsuru;M. Kuroki;M. Kuroki
中科院分区：
文献类型：
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作者：
H. Shibaguchi;H. Tsuru;M. Kuroki;M. Kuroki
在临床诊断中使用的低强度超声波，如腹部回声检查，是一种非侵入性治疗，比光更深地渗透到体内。最近，声动力疗法（SDT），它使用低强度超声与声敏剂，已被开发用于癌症治疗中应用超声的这些属性。到目前为止，已经开发的大多数声敏剂对光和超声敏感，这意味着在光动力治疗期间使用的光敏剂的缺点，例如皮肤敏感性，在SDT中仍然需要克服。然而，在最近的研究中报告了一些例外情况，其中致敏剂主要由超声波而不是由光激活。此外，最近的体内研究表明，SDT与声致敏剂具有很大的潜力，作为一种非侵入性和可重复的治疗癌症的治疗。
The low-intensity ultrasound that is used in clinical diagnoses, such as abdomen echo inspection, is a non-invasive treatment, and penetrates deeper into the body than light. Recently, sonodynamic therapy (SDT), which uses low-intensity ultrasound together with a sonosensitizer, has been developed for cancer therapy in applying such properties of ultrasound. So far, most sonosensitizers that have been developed are sensitive to light as well as ultrasound, implying that the shortcomings of photosensitizers used during photodynamic therapy, such as skin sensitivity, still need to be overcome in SDT. Some exceptions were, however, reported in recent studies in which sensitizers were activated mainly by ultrasound but not by light. Furthermore, recent in vivo studies have demonstrated that SDT with a sonosensitizer has a great potential as a non-invasive and repeatable treatment for cancer therapy.