Does HIV infection promote early kidney injury in women?
Does HIV infection promote early kidney injury in women?
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DOI：
10.3851/imp2677
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Shlipak, Michael G.
中科院分区：
文献类型：
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作者：
Jotwani, Vasantha;Scherzer, Rebecca;Shlipak, Michael G.
背景：在 HIV 感染女性中，新型肾小管间质损伤标志物、白细胞介素 18 (IL-18) 和肾损伤标志物 1 (KIM-1) 的尿液浓度与肾功能衰退和全因死亡率相关。我们假设，通过尿液损伤标志物确定，与未感染的对照相比，肾滤过功能保留的 HIV 感染者会出现更广泛的肾损伤，并且肾小管间质损伤的危险因素将不同于白蛋白尿的危险因素。方法：在这项横断面研究中，我们比较了 908 名 HIV 感染者和 289 名 HIV 感染者的尿液中 IL-18、KIM-1 和白蛋白肌酐比值 (ACR) 的浓度。未感染 HIV 的女性参加了妇女机构间 HIV 研究，利用了 1999 年至 2000 年间储存的尿液样本。结果：经过多变量调整线性回归分析，HIV 感染者的平均尿液中 IL-18 浓度高出 38%（P
Background: In HIV-infected women, urine concentrations of novel tubulointerstitial injury markers, interleukin-18 (IL-18) and kidney injury marker-1 (KIM-1), are associated with kidney function decline and all-cause mortality. We hypothesized that HIV-infected individuals with preserved kidney filtration function would have more extensive kidney injury, as determined by urine injury markers, compared to the uninfected controls, and that risk factors for tubulointerstitial injury would differ from risk factors for albuminuria.Methods: In this cross-sectional study, we compared urine concentrations of IL-18, KIM-1 and albumin-tocreatinine ratio (ACR) in 908 HIV-infected and 289 HIV-uninfected women enrolled in the Women's Interagency HIV Study, utilizing stored urine specimens from visits between 1999 and 2000.Results: After multivariate-adjusted linear regression analysis, mean urine concentrations were higher in HIV-infected individuals by 38% for IL-18 (P