Human contact with bait containing vaccine for control of rabies in wildlife.
Human contact with bait containing vaccine for control of rabies in wildlife.
复制标题
人类接触含有控制野生动物狂犬病疫苗的诱饵。
DOI：
10.2460/javma.1998.213.10.1413
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Charles E. Rupprecht
中科院分区：
文献类型：
--
作者：
Michael W. McGuill;Silvia M. Kreindel;Alfred DeMaria;Alison H. Robbins;Steven Rowell;Cathleen A. Hanlon;Charles E. Rupprecht
OBJECTIVE
To document the number of human contacts with bait containing liquid vaccinia-rabies glycoprotein (V-RG) vaccine, to evaluate factors that might affect human contact with bait-vaccine units, and to summarize adverse reactions in people after contact with vaccine.
DESIGN
Retrospective 4-year survey of directors of 6 oral rabies vaccination programs.
SAMPLE POPULATION
Human residents in areas of vaccination programs.
PROCEDURE
Data were collected from report forms and telephone conversations with directors of oral rabies vaccination programs in Florida, Massachusetts, New Jersey, Texas, and New York. Data collected included information regarding human contact with bait and vaccine, sex and age of person involved in contact, human population density, bait density, type of labeling used on bait, and other factors.
RESULTS
Human contact with bait was more likely in areas where bait had white labels (vs lettering in black ink) and in areas with high human population densities. Directors of all programs reported that human contact with bait-vaccine units was minimal. Adverse reactions in exposed people were not reported. On the basis of these findings, concerns about V-RG vaccine posing a substantial public health risk remain unfounded.
CLINICAL IMPLICATIONS
Directors of oral rabies vaccination programs should systematically collect information about exposures and potential factors affecting exposure of people to bait-vaccine units. People with substantial exposure to V-RG vaccine should be evaluated for immune status and any resulting symptoms should be documented and monitored.
