Role of the dopaminergic nigrostriatal pathway in methamphetamine-induced depression of the neostriatal serotonergic system.
Role of the dopaminergic nigrostriatal pathway in methamphetamine-induced depression of the neostriatal serotonergic system.
复制标题
多巴胺能黑质纹状体通路在甲基苯丙胺诱导的新纹状体血清素能系统抑制中的作用。
DOI：
10.1016/0014-2999(87)90616-9
复制
发表时间：
1987
影响因子：
5
通讯作者：
Gibb,JW
中科院分区：
文献类型：
--
作者：
Johnson,M;Stone,DM;Hanson,GR;Gibb,JW
The prevention of the decrease in neostriatal trytophan hydroxylase (TPH) activity with a single dose of methamphetamine (MA) was attempted by lesioning the nigrostriatal dopaminergic projections with bilateral nigral injections of 6-hydroxydopamine (6-OHDA). The rats were injected with MA (10 mg/kg) 11 days later, and killed 3 h after the injection. The 6-OHDA lesions prevented the decrease of TPH activity in the neostriatum, while the decrease of enzyme activity was slightly attenuated in the hippocampus and unaffected in the frontal cortex. This study demonstrates: (1) that the attenuation of TPH activity can be prevented in a selected brain area by destroying its dopaminergic afferents, and (2) implicates central dopamine (DA), or its metabolite, in the decrease in central TPH activity observed after a single injection of MA.
