PADI4 rs2240337 G>A polymorphism is associated with susceptibility of esophageal squamous cell carcinoma in a Chinese population.
PADI4 rs2240337 G>A polymorphism is associated with susceptibility of esophageal squamous cell carcinoma in a Chinese population.
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PADI4 rs2240337 G > 多态性与中国人群食管鳞状细胞癌易感性相关
DOI：
10.18632/oncotarget.20675
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发表时间：
2017-11-07
期刊：
影响因子：
--
通讯作者：
Yin J
中科院分区：
文献类型：
--
作者：
Wang L;Gu H;Long T;Pan H;Lv L;Shi Y;Zhu J;Sun Y;Tang W;Ding G;Chen S;Fan Y;Ding H;Qian C;Wang Q;Yao J;Tan L;Yin J
食道癌仍然是世界范围内癌症发病率和死亡率的主要原因之一。遗传因素，如单核苷酸多态(SNPs)，可能与食管癌的发生有关。我们进行了一项以医院为基础的病例对照研究，以评估SNPs对EC发生发展的遗传易感性。共有629例食管鳞癌(ESCC)患者和686例正常对照进入本研究。采用连接检测反应法对7个PADI4单核苷酸多态进行检测。我们的研究结果表明，PADI4 rs2240337 GA/AA变异与ESCC的风险降低显著相关。单倍型PADI4 Ars2477137Crs1886302Grs11203366Grs16825533Grs2240337Ars1635564Ars1635562和Crs2477137Trs1886302Grs11203366Ars1635564Grs2240337Crs1635564Trs1635562基因多态性与食管鳞癌易感性降低相关，而Crs2477137Trs1886302Ars11203366Ars1635564Grs2240337Ars1635564Ars1635562与食管癌易感性增加相关。分层分析显示，吸烟显著增加PADI4基因rs11203366 AG/AA、rs1886302 CC/CT、rs1635562 AT、rs1635564 CA和rs2477137 AC基因的ESCC风险。饮酒增加PADI4基因rs11203366 AG、rs1635562 AT、rs1635564 CA、rs2477137 AC、rs1886302 CT基因突变。在较年轻的队列中(63岁)，rs11203366 AA基因型与ESCC风险增加相关。在女性队列中，PADI4 rs1886302 CC变异与ESCC易感性相关。我们的研究提示，PADI4rs2240337G>；A基因多态性可能与食管鳞癌的个体易感性有关。PADI4基因rs11203366、rs1886302、rs1635562、rs1635564和rs2477137基因多态与食管癌易感性的性别、年龄、吸烟和饮酒有关。然而，在不同种族人群中进行更大规模的研究，以及使用基因突变细胞或动物进行进一步的实验，都是有必要验证我们的结论的。
Esophageal cancer (EC) remains one of the major causes of cancer incidence and mortality worldwide. Genetic factors, such as single nucleotide polymorphisms (SNPs), may contribute to the carcinogenesis of EC. We conducted a hospital based case-control study to evaluate the genetic susceptibility of SNPs on the development of EC. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. Seven PADI4 SNPs were determined by ligation detection reaction method. Our findings suggested that the PADI4 rs2240337 GA/AA variants were significantly associated with decreased risk of ESCC. Haplotype PADI4 Ars2477137Crs1886302Grs11203366Grs16825533Grs2240337Ars1635564Ars1635562 and Crs2477137Trs1886302Grs11203366Ars1635564Grs2240337Crs1635564Trs1635562 polymorphism was correlated with decreased susceptibility to ESCC, while Crs2477137Trs1886302Ars11203366Ars1635564Grs2240337Ars1635564Ars1635562 was correlated with increased susceptibility of ESCC. Stratification analyses demonstrated that smoking significantly increased ESCC risk in PADI4 rs11203366 AG/AA, rs1886302 CC/CT, rs1635562 AT, rs1635564 CA and rs2477137 AC genotype. Alcohol drinking increased ESCC risk in PADI4 rs11203366 AG, rs1635562 AT, rs1635564 CA, rs2477137 AC, rs1886302 CT genotype. In younger cohort (<63 years), rs11203366 AA genotype was associated with increased risk of ESCC. PADI4 rs1886302 CC variant was associated with ESCC susceptibility in female cohort. Our study suggested that PADI4 rs2240337 G>A polymorphism may be correlated with individual susceptibility to ESCC. PADI4 rs11203366, rs1886302, rs1635562, rs1635564 and rs2477137 polymorphisms were implicated with altered susceptibility of ESCC based on sex, age, smoking status and alcohol consumption. However, larger studies among different ethnic populations and further experiments using genetically mutated cells or animals are warranted to verify our conclusion.
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影响因子：
3.8
作者：
Chang X;Han J;Pang L;Zhao Y;Yang Y;Shen Z
通讯作者：
Shen Z
DOI：
10.1006/bbrc.2001.6303
发表时间：
2002-01-25
影响因子：
3.1
作者：
Hagiwara, T;Nakashima, K;Yamada, M
通讯作者：
Yamada, M
影响因子：
5.3
作者：
Denis, Helene;Deplus, Rachel;Fuks, Francois
通讯作者：
Fuks, Francois
影响因子：
5.3
作者：
Li, Pingxin;Yao, Hongjie;Wang, Yanming
通讯作者：
Wang, Yanming
影响因子：
56.9
作者：
Wang, Y;Wysocka, J;Coonrod, SA
通讯作者：
Coonrod, SA