Inference on microsatellite mutation processes in the invasive mite, Varroa destructor, using reversible jump Markov chain Monte Carlo
Inference on microsatellite mutation processes in the invasive mite, Varroa destructor, using reversible jump Markov chain Monte Carlo
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DOI：
10.1016/j.tpb.2005.07.005
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发表时间：
2006-03-01
影响因子：
1.4
通讯作者：
Solignac, M
中科院分区：
文献类型：
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作者：
Cornuet, JM;Beaumont, MA;Solignac, M
狄斯瓦螨是东方蜜蜂的寄生螨。五十年前，两个不同的进化谱系（韩国和日本）入侵西方蜜蜂Apis mellifera。这种单倍-二倍体寄生虫主要通过兄妹交配繁殖，这是一种很大程度上有利于固定新突变的系统。在全球范围内从21个地点收集的西方蜜蜂的225个个体的样本中，在19个微卫星位点进行了分析，观察到一系列的从头突变。使用历史数据有关的入侵，这个原始的生物系统已被利用来比较三个突变模型与等位基因大小的限制微卫星标记：逐步（SMM）和广义（GSM）突变模型，和突变率随微卫星长度（ESM）呈指数增长的模型。后验概率的三个模型已估计为每个位点分别使用可逆跳马尔可夫链蒙特卡罗。每个模型的相对支持度在不同位点之间差异很大，但GSM是唯一一个总是获得至少9%支持度的模型，无论位点如何。该分析还提供了每个基因座的突变参数和两个入侵谱系的分歧时间的稳健估计（67，000代，90%可信区间为35，000 - 174，000）。平均每年10代，这种分歧时间与最后一次冰后期朝鲜-日本陆地分离相吻合。(c)2005年爱思唯尔公司All rights reserved.
Varroa destructor is a parasitic mite of the Eastern honeybee Apis cerana. Fifty years ago, two distinct evolutionary lineages (Korean and Japanese) invaded the Western honeybee Apis mellifera. This haplo-diploid parasite species reproduces mainly through brother sister matings, a system which largely favors the fixation of new mutations. In a worldwide sample of 225 individuals from 21 locations collected on Western honeybees and analyzed at 19 microsatellite loci, a series of de novo mutations was observed. Using historical data concerning the invasion, this original biological system has been exploited to compare three mutation models with allele size constraints for microsatellite markers: stepwise (SMM) and generalized (GSM) mutation models, and a model with mutation rate increasing exponentially with microsatellite length (ESM). Posterior probabilities of the three models have been estimated for each locus individually using reversible jump Markov Chain Monte Carlo. The relative support of each model varies widely among loci, but the GSM is the only model that always receives at least 9% support, whatever the locus. The analysis also provides robust estimates of mutation parameters for each locus and of the divergence time of the two invasive lineages (67,000 generations with a 90% credibility interval of 35,000-174,000). With an average of 10 generations per year, this divergence time fits with the last post-glacial Korea Japan land separation. (c) 2005 Elsevier Inc. All rights reserved.