Synthesis of biaryls and polyaryls by ligand-free Suzuki reaction in aqueous phase
Synthesis of biaryls and polyaryls by ligand-free Suzuki reaction in aqueous phase
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水相无配体 Suzuki 反应合成联芳基和多芳基
DOI：
10.1021/jo060122v
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发表时间：
2006-05-12
影响因子：
3.6
通讯作者：
Xin, BW
中科院分区：
文献类型：
--
作者：
Liu, LF;Zhang, YH;Xin, BW
在空气中、35℃、短反应时间（0.5-1小时）内开发了水相中高效的乙酸钯催化的无配体 Suzuki 反应。这种成功的催化体系的关键是在水相中使用适量的共溶剂。该方法可以扩展到连续多铃木偶联，在温和的反应条件（60℃）下，一锅法制备出高选择性和优异产率的聚芳基化合物。
A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction in aqueous phase was developed in short reaction times (0.5-1 h) at 35 degrees C in air. The key for such a successful catalytic system was the use of a suitable amount of cosolvents in the aqueous phase. The method could be extended to the consecutive multi-Suzuki coupling, and polyaryls were prepared in a single one-pot step in high selectivity and excellent yield under mild reaction conditions (60 degrees C).