REGULATION OF DOPAMINE FUNCTION IN THE PREFRONTAL CORTEX OF THE RAT BY THE THALAMIC MEDIODORSAL NUCLEUS
REGULATION OF DOPAMINE FUNCTION IN THE PREFRONTAL CORTEX OF THE RAT BY THE THALAMIC MEDIODORSAL NUCLEUS
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DOI：
10.1016/0361-9230(87)90159-6
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发表时间：
1987-07-01
影响因子：
3.8
通讯作者：
PHILLIPSON, OT
中科院分区：
文献类型：
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作者：
JONES, MW;KILPATRICK, IC;PHILLIPSON, OT
对大鼠单侧操作丘脑内侧背核(MD)后，前额叶皮质内侧核(FCx)和无颗粒岛叶皮质(AgCx)的多巴胺(DA)利用进行了评估。以3，4-二羟基苯乙酸(DOPAC)：DA和4-羟基-3-甲氧基苯乙酸(HVA)：DA的比值作为DA利用的指标，并显示电刺激外侧MD后同侧FCX的DA利用率增加。虽然在这种情况下，FCX中DA利用率的增加是双侧的，但在向外侧MD注入兴奋性毒素牛磺酸钠1小时后，观察到了类似的反应。在ibotenate治疗后较长的恢复期(2天和1周)，DA利用率已恢复到接近对照组的值，到1周时，对侧FCX的HVA：DA显著下降。所有处理对AgCx中DA的利用几乎没有影响，尽管在电刺激和短期注射ibotenate后有提高比率的趋势。这些发现表明，刺激MD神经元可能倾向于激活其皮质会聚终末区域的DA系统。这些影响是在DA终末水平上相互作用的结果，而不是在中皮质DA神经元胞体上的相互作用。
Dopamine (DA) utilisation has been assessed in the medial bank of the prefrontal cortex (FCx) and the agranular insular cortex (AgCx) of the rat in response to unilateral manipulations of the thalamic mediodorsal nucleus (MD). The ratios of 3,4-dihydroxyphenylacetic acid (DOPAC):DA and 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid, HVA):DA are used as indices of DA utilisation and were shown to increase in the ipsilateral FCx following electrical stimulation of lateral MD. A similar response was observed 1 hr after an infusion of the excitotoxin sodium ibotenate into lateral MD, although in this case the increase in DA utilisation in FCx was bilateral. Longer periods of recovery after ibotenate treatment (2 day and 1 week) produced DA utilisation ratios that had returned to near control values and by 1 week a significant decrease was detected in HVA:DA of the contralateral FCx. All treatments had little effect on DA utilisation in AgCx, although there was a tendency towards enhanced ratios after electrical stimulation and short-term ibotenate injection. These findings suggest that stimulation of MD neurones may tend to activate the DA system in their convergent terminal regions of cortex. It is argued that these influences result from interactions at the level of the DA terminal rather than at the cell bodies of mesocortical DA neurones.