Biochemical studies on the potentiation of antitumor activity of cisplatin by adriamycin.
Biochemical studies on the potentiation of antitumor activity of cisplatin by adriamycin.
复制标题
阿霉素增强顺铂抗肿瘤活性的生化研究。
DOI：
10.1016/s0006-291x(83)80183-1
复制
发表时间：
1983
影响因子：
3.1
通讯作者：
Harder,HC
中科院分区：
文献类型：
--
作者：
Chuang,RY;Ramlet,JS;Harder,HC
The RNA synthesisinvitrobyE. coliRNA polymerase was found to be highly sensitive to cis-diamminedichloroplatinum (cisplatin) inhibition. The degree of inhibition was in proportion to the length of time of template preincubation with cisplatin, suggesting that cisplatin-template binding was involved in the inhibition of RNA polymerase. The effect of adriamycin on this inhibition was studied and it was found that adriamycin significantly enhanced the inhibitory effect of cisplatin and that the total effect was greater than the sum of the effects of each drug used individually. This synergistic effect was not observed when the effect of the combination of adriamycin and cisplatin oninvitroDNA synthesis was studied.
