Contributions of the host microenvironment to cancer-induced bone disease.
Contributions of the host microenvironment to cancer-induced bone disease.
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DOI：
10.1158/0008-5472.can-13-2645
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发表时间：
2014-03-15
期刊：
影响因子：
11.2
通讯作者：
Edwards CM
中科院分区：
文献类型：
--
作者：
Olechnowicz SW;Edwards CM
骨髓为肿瘤生长和相关骨疾病的发展提供了专门的和高度支持的微环境。它是乳腺癌和前列腺癌骨转移和血液恶性肿瘤多发性骨髓瘤的首选部位。多年来，研究人员一直专注于肿瘤细胞与直接负责骨重建的细胞（即破骨细胞和成骨细胞）之间的相互作用。然而，越来越多的证据表明，骨髓微环境可以通过多种方式促进疾病的发病机制，包括通过癌症相关的成纤维细胞、造血干细胞生态位、骨髓源性抑制细胞和交感神经系统。本文综述了近年来我们对宿主微环境对癌症引起的骨疾病发展的贡献的认识。
The bone marrow provides a specialised and highly supportive microenvironment for tumour growth and development of the associated bone disease. It is a preferred site for breast and prostate cancer bone metastasis and the haematological malignancy, multiple myeloma. For many years, researchers have focused upon the interactions between tumour cells and the cells directly responsible for bone remodelling, namely osteoclasts and osteoblasts. However, there is ever-increasing evidence for a multitude of ways in which the bone marrow microenvironment can promote disease pathogenesis, including via cancer-associated fibroblasts, the hematopoietic stem cell niche, myeloid-derived suppressor cells and the sympathetic nervous system. This review discusses the recent advances in our understanding of the contribution of the host microenvironment to the development of cancer-induced bone disease.