The Barriers and Motivators to Using Human Tissues for Research: The Views of UK-Based Biomedical Researchers
The Barriers and Motivators to Using Human Tissues for Research: The Views of UK-Based Biomedical Researchers
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DOI：
10.1089/bio.2019.0138
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发表时间：
2020-06-17
影响因子：
1.6
通讯作者：
Quinlan, Philip R.
中科院分区：
文献类型：
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作者：
Lawrence, Emma;Sims, Jessica;Quinlan, Philip R.
引言：人源性样本的使用对于生物学和医学研究的许多领域至关重要。尽管如此，研究人员经常发现或预期在采购样本方面存在困难。目前正在努力提高英国人体组织生物库的可见度和可及性，但对研究人员选择样本来源的原因进行的研究很少（如果有的话）。我们分析了英国研究人员使用他们首选的样本来源的动机和他们对人类样本使用的感知障碍。方法：该研究基于对学术和行业研究人员的在线调查，随后是焦点小组，参与者遍布英国。调查和焦点小组都探讨了参与者对在研究中发现和使用人类样本的障碍的看法。结果：198名学术和行业研究人员完成了对他们的人体样本使用的调查，并进行了由21名参与者组成的5个焦点小组。选择来源的主要原因包括相关临床数据的可用性（40%），资源的地理位置（39%）和预先存在的合作（33%）。重点小组的参与者强调，他们强烈倾向于当地或已知的样本来源，因为他们的工作可以获得更多的科学和后勤投入，他们对样本的质量更有信心。讨论：我们发现，有显着的看法治理障碍样本访问。因此，研究人员更喜欢当地和知名的供应商，因为他们认为这些供应商可以帮助治理，可靠，并能够提供他们所需的额外支持。同样，数据的可得性也是选择新的样本来源的一个主要因素。这些观察结果对于那些寻求通过在线发现工具改善对现有样本资源的访问的人具有重要价值。
Introduction:The use of human-derived samples is vital to numerous areas of biological and medical research. Despite this, researchers often find or anticipate difficulty in sourcing samples. There are ongoing efforts to increase the visibility and accessibility of UK human tissue biobanking, but minimal (if any) research on the reasons behind researchers' choice of sample source has been undertaken. We have analyzed UK researchers' motivations on using their preferred sample sources and their perceived barriers to human sample use. Methods:The study was based on an online survey of academic and industry researchers, followed by focus groups, with participants across the United Kingdom. Both the survey and focus groups probed participants' views on the barriers to finding and using human samples in research. Results:One hundred ninety-eight academic and industry researchers completed the survey on their human sample use, and five focus groups consisting of 21 total participants took place. The top cited reasons for choosing sources included the availability of linked clinical data (40%), the geographical location of the resource (39%), and preexisting collaboration (33%). Focus group participants highlighted their strong preference for local or known sample sources, which were preferred because additional scientific and logistical input could be obtained for their work and they were more confident that the samples would be of good quality. Discussion:We found that there were significant perceptions of governance barriers to sample access. As a consequence, researchers preferred local and known suppliers because of the perception that these could assist with the governance, would be reliable, and able to provide the additional support they required. Equally, data availability was a major contributor to the selection of a new source of samples. These observations are of significant value to those seeking to improve the access to existing sample resources via online discovery tools.