Polar overdominance at the Ovine callipyge locus
Polar overdominance at the Ovine callipyge locus
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DOI：
10.1126/science.273.5272.236
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发表时间：
1996-07-12
期刊：
影响因子：
56.9
通讯作者：
Georges, M
中科院分区：
文献类型：
--
作者：
Cockett, NE;Jackson, SP;Georges, M
最近在绵羊中描述了一种可遗传的肌肉肥大，并表明是由定位于绵羊18号染色体的callipyge基因决定的。在这里，callipyge表型被发现的特点是一个非孟德尔遗传模式，称为极性超显性，其中只有杂合子个体遗传了callipyge突变从他们的父亲表达的表型。父母的印记在极性超显性决定论的可能作用的设想。
An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.