CEREBROSPINAL-FLUID IMMUNOREACTIVE BETA-ENDORPHIN CONCENTRATION IS INCREASED BY VOLUNTARY EXERCISE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
CEREBROSPINAL-FLUID IMMUNOREACTIVE BETA-ENDORPHIN CONCENTRATION IS INCREASED BY VOLUNTARY EXERCISE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
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DOI：
10.1016/0167-0115(90)90021-n
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发表时间：
1990-04-24
影响因子：
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通讯作者：
THOREN, P
中科院分区：
文献类型：
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作者：
HOFFMANN, P;TERENIUS, L;THOREN, P
本文研究了运动对自发性高血压大鼠(SHR)脑脊液(CSF)免疫活性β-内啡肽水平的影响。锻炼包括5-6周的自发性车轮跑步，平均跑步距离为3.5+-。0.4公里/24小时，麻醉下从枕大池取脑脊液标本。五个试验组接受了检查，四组跑步者和一组久坐的对照组。跑步者在运动结束后即刻(0-3h)或在车轮锁定24、48或96h后取样。A组跑步者的β-内啡肽免疫反应水平显著高于对照组。强制戒断24小时和48小时后，血浆β-内啡肽水平仍高于对照组，但96小时后恢复到对照组水平。数据表明，自愿运动可引起中枢β-内啡肽系统的适应性变化。
The effect of voluntary exercise on cerebrospinal fluid (CSF) levels of immunoreactive .beta.-endorphin has been studied in the spontaneously hypertensive rat (SHR). The exercise consisted of 5-6 weeks of spontaneous running in wheels and the average running distance was 3.5 .+-. 0.4 km/24 h. CSF samples were obtained under anaesthesia from the cisterna magna. Five experimental groups were examined, four groups of runners and one group of sedentary controls. The runners were sampled either (a) shortly (0-3 h) after termination of exercise, or after the wheel had been locked for (b) 24, (c) 48 or (d) 96 h. The runners in group a had significantly higher immunoreactive .beta.-endorphin levels than the controls. The levels remained increased as compared with controls after 24 and 48 h of enforced abstinence but had returned to control after 96 h. The data indicate that voluntary exercise induces adaptive changes in central .beta.-endorphin systems.