An Outbreak of 2009 Pandemic Influenza A (H1N1) Virus Infection in an Elementary School in Pennsylvania
An Outbreak of 2009 Pandemic Influenza A (H1N1) Virus Infection in an Elementary School in Pennsylvania
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DOI：
10.1093/cid/ciq058
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发表时间：
2011-01-01
影响因子：
11.8
通讯作者：
Swerdlow, David
中科院分区：
文献类型：
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作者：
Marchbanks, Tiffany L.;Bhattarai, Achuyt;Swerdlow, David
2009年5月，2009年大流行性甲型流感病毒（pH1N1）感染的最早爆发之一导致宾夕法尼亚州一所半农村的小学关闭。对313个家庭的1345名学生（占在校学生的85%）和家庭成员进行了两次连续电话调查，以收集流感样疾病（ILI）的数据。ILI报告说，在接受调查的家庭中，共有167人（12.4%），其中包括93名A学校学生（24.0%）。学生患ILI的可能性是其他家庭成员的3.1倍（95%可信区间[CI]， 2.3-4.1）。四年级学生比其他年级的学生更容易受到影响（相对风险，2.2;95% CI, 1.2-3.9）。实时逆转录酶聚合酶链反应检测26例（72.2%）人感染pH1N1。在学校关闭7天后重新开学后，疫情没有恢复。调查发现，学校爆发甲型h1n1流感的发病率很高；然而，年级和教室受到的影响是不同的。有必要进行进一步研究，以确定疫情期间关闭学校的有效性。
In May 2009, one of the earliest outbreaks of 2009 pandemic influenza A virus (pH1N1) infection resulted in the closure of a semi-rural Pennsylvania elementary school. Two sequential telephone surveys were administered to 1345 students (85% of the students enrolled in the school) and household members in 313 households to collect data on influenza-like illness (ILI). A total of 167 persons (12.4%) among those in the surveyed households, including 93 (24.0%) of the School A students, reported ILI. Students were 3.1 times more likely than were other household members to develop ILI (95% confidence interval [CI], 2.3-4.1). Fourth-grade students were more likely to be affected than were students in other grades (relative risk, 2.2; 95% CI, 1.2-3.9). pH1N1 was confirmed in 26 (72.2%) of the individuals tested by real-time reverse-transcriptase polymerase chain reaction. The outbreak did not resume upon the reopening of the school after the 7-day closure. This investigation found that pH1N1 outbreaks at schools can have substantial attack rates; however, grades and classrooms are affected variably. Additioanl study is warranted to determine the effectiveness of school closure during outbreaks.