PREVALENCE OF BIRTH-DEFECTS AMONG LOW-BIRTH-WEIGHT INFANTS - A POPULATION STUDY
PREVALENCE OF BIRTH-DEFECTS AMONG LOW-BIRTH-WEIGHT INFANTS - A POPULATION STUDY
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DOI：
10.1001/archpedi.1991.02160110105032
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发表时间：
1991-11-01
影响因子：
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通讯作者：
MCCLEARN, AB
中科院分区：
文献类型：
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作者：
MILI, F;EDMONDS, LD;MCCLEARN, AB
大约 3% 至 4% 的婴儿在出生第一年就被诊断出患有严重出生缺陷。由于许多出生缺陷婴儿患有宫内发育迟缓、早产或两者兼而有之，因此出生缺陷的发生率无疑会根据婴儿的出生体重而有所不同。然而，据我们所知，这种变异的程度尚未在明确的人群中得到充分研究。我们分析了 1978 年至 1988 年以人口为基础的亚特兰大大都会 (佐治亚州) 先天缺陷计划的数据。这些数据包括 317 499 名单胎活产婴儿中 11 398 名被诊断患有严重出生缺陷的婴儿的信息。尽管总体出生缺陷率为 3.6%，但我们观察到出生缺陷率与婴儿出生体重之间存在惊人的负相关关系。出生时体重小于1500克的新生儿出生缺陷率为16.2%，1500克至1999克的新生儿出生缺陷率为13.2%，2000克至2499克的新生儿出生缺陷率为6.2%，2500克至3999克的新生儿出生缺陷率为3.2%，4000克或4000克的新生儿出生缺陷率为2.8%。更多。按缺陷类型进行的分析表明，大多数出生缺陷与低出生体重显着相关。低出生体重婴儿出生缺陷的风险较高，这表明出生缺陷会导致低出生体重婴儿的发病率过高。由于出生缺陷和低出生体重之间的重叠，人口中低出生体重的预防在很大程度上取决于对低出生体重的复杂病因的更好认识，部分取决于对影响出生缺陷发生的危险因素的描述。
Major birth defects are diagnosed in about 3% to 4% of infants during their first year of life. Because many infants with birth defects have intrauterine growth retardation, are born prematurely, or both, the rate of birth defects undoubtedly varies according to the infant's birth weight. Nevertheless, the magnitude of such variation has not, to our knowledge, been adequately studied in well-defined populations. We analyzed data from the population-based Metropolitan Atlanta (Ga) Congenital Defects Program for 1978 through 1988. These data included information on 11 398 infants who were diagnosed with serious birth defects among 317 499 singleton live-born infants. Although the overall rate of birth defects was 3.6%, we observed a striking inverse relationship between the birth defects rate and the infants' birth weights. The birth defect rates were 16.2% for newborns weighing less than 1500 g at birth, 13.2% for newborns weighing from 1500 g to 1999 g, 6.2% for newborns weighing from 2000 g to 2499 g, 3.2% for newborns weighing from 2500 g to 3999 g, and 2.8% for newborns weighing 4000 g or more. Analyses by type of defect indicated that most birth defects were significantly associated with low birth weight. The higher risk of birth defects among low-birth-weight infants demonstrates that birth defects contribute to excess morbidity among low-birth-weight infants. Because of the overlap between birth defects and low birth weight, the prevention of low birth weight in the population depends greatly on a better recognition of the complex etiology of low birth weight and, in part, on the delineation of risk factors that influence the occurrence of birth defects.