1,8-Naphthalimide hydroperoxides as novel intercalating DNA cleavers
1,8-Naphthalimide hydroperoxides as novel intercalating DNA cleavers
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DOI：
10.1016/0143-7208(95)00105-0
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发表时间：
1996-07
影响因子：
4.5
通讯作者：
Z. Tao;X. Qian;D. Wei
中科院分区：
文献类型：
--
作者：
Z. Tao;X. Qian;D. Wei
Two new naphthalimide hydroperoxides 3 and 4 have been synthesized and their interactions with DNA investigated. They efficiently intercalate into (in the dark) and cleave (under irradiation, 365 nm) pBR322 and pUC19 DNA. Their DNA-cleaving activities depend on incubation time and temperature in the dark, concentration of drugs, and types of buffers. In contrast, DNA cleavage by 1, a phthalimide peroxide that has been reported to act as a DNA cleaver, was not visible under the same condition.
