Galantamine in frontotemporal dementia and primary progressive aphasia
Galantamine in frontotemporal dementia and primary progressive aphasia
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DOI：
10.1159/000113034
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Brashear, R.
中科院分区：
文献类型：
--
作者：
Kertesz, A.;Morlog, D.;Brashear, R.
背景/目的：额颞叶痴呆（FTD）的治疗主要是对症治疗。神经递质的小型随机或开放标签病例对照研究尚未得出结论。我们在2种最常见的FTD中尝试了加兰他敏。方法：36例行为多样性FTD和原发性进行性失语（PPA）患者在18周开放标签期和8周随机安慰剂对照期接受加兰他敏治疗。主要疗效指标为额叶行为量表、西方失语症成套测验的失语商数、严重程度临床总体印象和改善临床总体印象。结果：整个组在行为或语言方面没有显著差异。在安慰剂对照停药期，在PPA受试者亚组中，总体严重程度评分显示治疗效果（p = 0.009）有利于加兰他敏，但在多重比较校正后，认为不具有显著性。与安慰剂组相比，PPA治疗组的语言评分也保持稳定，后者表现出恶化。结论：加兰他敏对FTD的行为变化无效，但在失语症亚组中显示出疗效趋势，可能具有临床意义。加兰他敏在FTD/PPA中似乎是安全的。版权所有（C）2008 S. Karger AG，巴塞尔。
Background/Aims: The treatment of frontotemporal dementia (FTD) has been mainly symptomatic. Small randomized or open-label case control studies of neurotransmitters have been inconclusive. We tried galantamine in the 2 most common varieties of FTD. Method: Thirty-six behavioral variety FTD and primary progressive aphasia (PPA) patients were treated in an open-label period of 18 weeks and a randomized, placebo-controlled phase for 8 weeks with galantamine. The primary efficacy measures were the Frontal Behavioral Inventory, the Aphasia Quotient of the Western Aphasia Battery, the Clinical Global Impression of Severity and the Clinical Global Impression of Improvement. Results: No significant differences in behavior or language were found for the total group. A treatment effect (p = 0.009), in a subgroup of subjects with PPA in the global severity score, in favor of galantamine was detected in the placebo-controlled withdrawal phase but was not considered significant after correction for multiple comparisons. The language scores for the treated PPA group also remained stable compared to the placebo group, which showed deterioration. Conclusion: Galantamine is not effective in the behavioral variety of FTD, but a trend of efficacy is shown in the aphasic subgroup, which may be clinically significant. Galantamine appeared safe in FTD/PPA. Copyright (C) 2008 S. Karger AG, Basel.