Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling.
Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling.
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DOI：
10.3390/vetsci3040027
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发表时间：
2016-09-28
影响因子：
2.4
通讯作者：
Pedra JHF
中科院分区：
文献类型：
--
作者：
Shaw DK;McClure EE;Wang X;Pedra JHF
面对攻击，宿主细胞会立即做出由先天免疫组织策划的反应。两个最好描述的先天免疫信号传导网络是Toll样受体途径和Nod样受体途径。已经做了大量的工作，表征两个信号级联与炎性体生物学前沿的几个最新进展。在这篇综述中，我们将讨论如何更常见的研究病原体不同于蜱传播的微生物的背景下，Nod样受体信号和炎性小体的形成。由于蜱传播的病原体具有独特的特征，我们认为这些微生物可用于揭示Nod样受体生物学的新原理。
In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology.