Neuroprotection in mice by NGP1-01 after transient focal brain ischemia
Neuroprotection in mice by NGP1-01 after transient focal brain ischemia
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DOI：
10.1016/j.brainres.2007.11.075
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发表时间：
2008-02-27
期刊：
影响因子：
2.9
通讯作者：
Bickel, Ulrich
中科院分区：
文献类型：
--
作者：
Hao, Jiukuan;Mdzinarishvili, Alexander;Bickel, Ulrich
The effect of the polycyclic cage amine NGP1-01, a dual action antagonist at both L-type calcium channels and NMDA receptors, was measured after transient (1 h) focal cerebral ischemia in the mouse middle cerebral artery occlusion (MCAO) model. Mice were left untreated, or received NGP1-01 (20 mg/kg per dose intraperitoneally), memantine (20 mg/kg per dose intraperitoneally), or vehicle (DMSO) at 15 min, 24 h and 48 h after reperfusion. Sensorimotor function was tested daily for two weeks using the "corner test", a proven paradigm for the assessment of functional integrity in rodents. NGP1-01 significantly reduced sensorimotor deficits over the 2-week period (p
