Caveolin, caveolae, and endothelial cell function
Caveolin, caveolae, and endothelial cell function
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DOI：
10.1161/01.atv.0000070546.16946.3a
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发表时间：
2003-07-01
影响因子：
8.7
通讯作者：
Lisanti, MP
中科院分区：
文献类型：
--
作者：
Frank, PG;Woodman, SE;Lisanti, MP
小凹是在终末分化细胞中观察到的 50 至 100 nm 细胞表面质膜内陷。它们在内皮细胞中特别丰富，被认为在内皮细胞囊泡运输和信号转导的调节中发挥着重要作用。使用caveolae-1缺陷型小鼠为研究caveolae和caveolin-1在内皮细胞功能调节中的作用提供了许多新的见解。这些新发现表明 Caveolin-1 在癌症、动脉粥样硬化和血管疾病的发病机制中发挥着重要作用。
Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1-deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease.