Seroprevalence of IgG antibodies against measles in a selected Polish population - do we need to be re-vaccinated?
Seroprevalence of IgG antibodies against measles in a selected Polish population - do we need to be re-vaccinated?
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DOI：
10.5114/ceji.2019.92789
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发表时间：
2019-01-01
影响因子：
1.3
通讯作者：
Ciepiela, Olga
中科院分区：
文献类型：
--
作者：
Holka, Justyna;Pawlak, Katarzyna;Ciepiela, Olga
简介： 麻疹是一种具有高度传染性但可预防的病毒性疾病。它的爆发出现在世界各地，而群体免疫力的下降排除了它的消除。高水平的针对病毒的 IgG 抗体可有效预防感染。本研究的目的：评估在我们实验室进行麻疹 IgG 检测的不同年龄水平的患者血清中抗麻疹 IgG 的血清阳性率。材料和方法：该研究于 2019 年 3 月至 6 月进行。回顾性分析包括 364 名受检测患者的麻疹特异性 IgG 结果。纳入受试者的年龄范围为 4 个月至 101 岁，中位年龄为 46 岁，平均年龄为 43 +/- 18 岁。在 DiaSorin Liaison (R) 自动分析仪上使用间接化学发光免疫分析进行抗麻疹 IgG 定量。结果：我们的结果显示血清阳性率为 78.02%。血清阳性受试者数量最少的是婴儿（0-1岁）组，比例为53.85%，19-38岁成人组为55.68%。年龄最大的患者组（70-101岁）血清阳性比例最高（100%），而60-69岁的成年人血清阳性比例为97.22%。结论：这些数据表明，儿童时期接种过一剂或两剂MMR疫苗的青壮年人群最容易受到感染，在与其他人接触的工作中，应重新接种疫苗以预防感染。麻疹。
Introduction: Measles is highly contagious, but preventable viral disease. Its outbreaks appear all over the world, and decreasing herd immunity excludes its elimination. High levels of IgG antibodies against a virus efficiently protects against infection.Aim of this study: To assess the seroprevalence of anti-measles IgG in the serum of patients at different age levels tested for measles IgG at our laboratory.Material and methods: The study was conducted from March to June of 2019. Retrospective analysis included results for measles-specific IgG from 364 tested patients. The age of enrolled subjects ranged from four months to 101 years, with a median age of 46, and a mean age of 43 +/- 18. Quantification of anti-measles IgG was performed using indirect chemiluminescence immunoassays on the DiaSorin Liaison (R) automated analyzer.Results: Our results showed a seropositivity ratio of 78.02%. The lowest number of seropositive subjects was in the group of infants (0-1 years old), with a ratio of 53.85%, and the group of adults of 19-38 years old at 55.68%. The group of the oldest patients (70-101 years old) had the highest ratio of seropositive subjects (100%), while adults of 60-69 years old had a seropositivity ratio of 97.22%.Conclusions: These data suggest that the group of young adults who were vaccinated with one or two doses of MMR vaccine in childhood are the most susceptible for infection, and when working in contact with other people, should be re-vaccinated for protection against measles.