Non-cirrhotic portal hypertension and pregnancy outcome
Non-cirrhotic portal hypertension and pregnancy outcome
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DOI：
10.1111/j.1447-0756.2008.00853.x
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发表时间：
2008-10-01
影响因子：
1.6
通讯作者：
Mittal, Suneeta
中科院分区：
文献类型：
--
作者：
Sumana, Gurunath;Dadhwal, Vatsla;Mittal, Suneeta
目的：非肝硬化性门脉高压症(NCPH)是发展中国家，尤其是亚洲地区门脉高压症的常见病因。最近的数据显示，与肝硬变相比，NCPH患者的生殖功能接近正常，妊娠结局良好。方法：对5例NCPH患者的12例妊娠结局进行评估。结果：本研究中，20%的患者在妊娠期间出现呕血，并成功地进行了处理。4名患者(80%)患有严重贫血(血红蛋白6-7g%)，3名患者(60%)患有血小板减少症。没有早产。在总共9名活产中，6名是阴道分娩，3名是剖腹产(根据产科指征进行剖腹产)。4例(44%)小于胎龄(SGA)。结论：NCPH患者生育能力正常，孕期呕血发生率无明显增加，SGA发生率增高，无择期剖宫产指征。
Objective: Non-cirrhotic portal hypertension (NCPH) is a common cause of portal hypertension in developing countries, especially Asia. Recent data have shown near-normal reproductive function and good pregnancy outcome for NCPH compared with cirrhosis. The aim of the present study was to evaluate complications during pregnancy and pregnancy outcome in women with NCPH.Methods: Twelve pregnancies in five patients with NCPH were evaluated.Results: In the present study, 20% of patients had hematemesis during pregnancy that was managed successfully. Four patients (80%) had severe anemia (hemoglobin 6-7 g%) and three (60%) had thrombocytopenia. There were no preterm births. Of a total of nine live births, six were vaginal deliveries and three were delivered by Cesarean section (performed for obstetric indications). Four babies (44%) were small for gestational age (SGA).Conclusions: The results show that patients with NCPH have normal fertility, no apparent increase in the incidence of hematemesis during pregnancy, an increased incidence of SGA babies and no indication for elective Cesarean delivery.