Adapting to dynamic stimulus-response values: differential contributions of inferior frontal, dorsomedial, and dorsolateral regions of prefrontal cortex to decision making.
Adapting to dynamic stimulus-response values: differential contributions of inferior frontal, dorsomedial, and dorsolateral regions of prefrontal cortex to decision making.
复制标题
DOI：
10.1523/jneurosci.0963-09.2009
复制
发表时间：
2009-09-02
期刊：
影响因子：
--
通讯作者：
Blair RJ
中科院分区：
文献类型：
--
作者：
Mitchell DG;Luo Q;Avny SB;Kasprzycki T;Gupta K;Chen G;Finger EC;Blair RJ
背内侧(DMFC)、背外侧前额叶皮质(DlFC)和额下回(IFG)都与解决决策冲突有关，无论这种冲突是通过在相似的反应之间进行选择还是在强化偶发事件逆转后进行选择而产生的。然而，区分它们各自的职能贡献的工作仍然是初步的。我们使用功能磁共振成像来描绘这些系统在两种形式的决策冲突中的功能作用。在dmfc和dlfc中，对决策冲突的反应增加了血氧水平依赖(BOLD)反应，无论冲突是在对象之间的相对值差异减小的背景下发生的，还是在增援应急逆转后的错误发生的情况下发生的。联合分析证实，DMFC和dlFC的重叠区域被这两种形式的决策冲突所激活。然而，与这些区域不同的是，可供选择方案的相对价值的减少并不影响联发援框架内的活动。此外，尽管前额叶皮质的三个区域都表现出对反转错误的增强活性，但只有dmfc和dlfc也受到反转过程中数值变化幅度的调节。这些数据参考DMFC、dlFC和IFG功能模型进行解释。
Dorsomedial (dmFC), dorsolateral prefrontal cortex (dlFC) and inferior frontal gyrus (IFG) have all been implicated in resolving decision conflict whether this conflict is generated by having to select between responses of similar value or by making selections following a reversal in reinforcement contingencies. However, work distinguishing their individual functional contributions remains preliminary. We used functional magnetic resonance imaging to delineate the functional role of these systems with regard to both forms of decision conflict. Within dmFC and dlFC, blood oxygen level-dependent (BOLD) responses increased in response to decision conflict regardless of whether the conflict occurred in the context of a reduction in the difference in relative value between objects, or an error following a reversal of reinforcement contingencies. Conjunction analysis confirmed that overlapping regions of dmFC and dlFC were activated by both forms of decision conflict. Unlike these regions, however, activity in IFG was not modulated by reductions in the relative value of available options. Moreover, although all three regions of prefrontal cortex showed enhanced activity to reversal errors, only dmFC and dlFC were also modulated by the magnitude of value change during the reversal. These data are interpreted with reference to models of dmFC, dlFC, and IFG functioning.