Long-term efficacy of tonsillectomy in chinese patients with IgA nephropathy
Long-term efficacy of tonsillectomy in chinese patients with IgA nephropathy
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DOI：
10.1159/000100431
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发表时间：
2007-01-01
影响因子：
4.2
通讯作者：
Li, Lei-shi
中科院分区：
文献类型：
--
作者：
Chen, Yu;Tang, Zheng;Li, Lei-shi
背景：探讨扁桃体切除术对中国地区免疫球蛋白A肾病患者远期临床缓解和肾脏存活率的影响。方法：我们对1983年至1999年间112例特发性IgA肾病患者进行了为期130个月的回顾性病例对照研究。54例患者行扁桃体切除术，58例患者未行扁桃体切除术。随访期间的临床缓解率和预测临床缓解率的变量采用X(2)检验和多因素Cox回归分析，肾存活率采用Kaplan-Meier分析。结果：截至2006年，随访时间为130+/-50.3个月(60-276个月)。随访期扁桃体摘除组临床缓解率为46.3%，未摘除扁桃体组为27.6%。多变量分析显示扁桃体切除不是肾脏临床缓解的独立影响因素(p=0.386)。经Kaplan-Meier分析，摘除扁桃体与不摘除扁桃体患者的肾脏存活率差异无统计学意义(p=0.059)。结论：扁桃体摘除术后IgAN患者的临床缓解率明显高于未摘除扁桃体的患者。但在130个月内，接受扁桃体摘除和不接受扁桃体摘除的IgAN患者的肾脏存活率很难有统计学差异。版权所有(C)2007 S.Karger AG，巴塞尔
Background: To investigate the clinical efficacy of tonsillectomy on long-term clinical remission and renal survival of immunoglobulin A nephropathy (IgAN) patients in China. Methods: We performed a 130-month retrospective case-control study of 112 patients with idiopathic biopsy-diagnosed IgAN from 1983 to 1999. Fifty-four patients underwent tonsillectomy and 58 patients did not. The clinical remission rate during follow-up and variables to predict clinical remission were estimated by chi(2) test and multivariate Cox regression analysis; renal survival was evaluated by Kaplan-Meier analysis. Results: Up to 2006, the follow-up period lasted 130 +/- 50.3 months (60-276 months). The clinical remission rate was 46.3% in patients with tonsillectomy and 27.6% in those without tonsillectomy during follow-up. Multivariate analysis demonstrated that tonsillectomy was not an independent impact factor for renal clinical remission (p = 0.386). By Kaplan-Meier analysis, there was no significant difference in renal survival rate between patients with tonsillectomy and those without tonsillectomy (p = 0.059). Conclusion: The clinical remission rate in IgAN patients with tonsillectomy was higher than that in patients without tonsillectomy during follow-up. But within 130 months, it was difficult to find statistical difference in renal survival between IgAN patients with and without tonsillectomy. Copyright (c) 2007 S. Karger AG, Basel