Adolescent and adult female rats differ in sensitivity to nicotine's activity effects
Adolescent and adult female rats differ in sensitivity to nicotine's activity effects
复制标题
DOI：
10.1016/j.pbb.2005.01.019
复制
发表时间：
2005-04-01
影响因子：
3.6
通讯作者：
Grunberg, NE
中科院分区：
文献类型：
--
作者：
Elliott, BM;Faraday, MM;Grunberg, NE
超过90%的吸烟者是在青春期开始吸烟的。本实验采用受试者间重复测量法，研究：(1)尼古丁对青春期和成年雌性Sprague-Dawley大鼠活动的急性影响（药物一期）；(2)初始尼古丁暴露年龄对未给予尼古丁时活动的影响（过渡阶段）；(3)初始尼古丁暴露年龄对后期尼古丁反应的影响（药物II期）。实验分为三个阶段。在药物I期，动物通过皮下注射0（生理盐水）、0.01、0.10、0.50或1.0 mg/kg尼古丁，持续12天，每天测量水平活性。在中间阶段（没有给药阶段），测量活性，但不给尼古丁。在第二阶段，同样的动物被给予与第一阶段相同的尼古丁剂量，持续12天，每天测量活动。药物I期显示了青春期和成年雌性大鼠之间的剂量反应差异。此外，在青春期开始接触尼古丁的动物比在成年期开始接触尼古丁的雌性动物对尼古丁的活性增加效应表现出更大的敏感性（即，药物II期）。版权所有。
More than 90% of cigarette smokers begin smoking during adolescence. This between-subjects repeated-measures experiment examined: (1) nicotine's acute effects on activity in adolescent and adult female Sprague-Dawley rats (Drug Phase 1); (2) the effects of age of initial nicotine exposure on activity when nicotine was not administered (Interim Phase); and (3) the effects of age of initial nicotine exposure on later responses to nicotine (Drug Phase II). The experiment consisted of three separate phases. In Drug Phase I, animals were administered either 0 (saline), 0.01, 0.10, 0.50, or 1.0 mg/kg nicotine via subcutaneous injections for 12 days and horizontal activity was measured daily. During the Interim Phase (no drug phase), activity was measured but nicotine was not administered. During Drug Phase II, the same animals were administered the same nicotine dosages as in Drug Phase I for 12 days and activity was measured daily. Drug Phase I revealed dose-response differences between adolescent and adult female rats. in addition, animals initially exposed to nicotine in adolescence exhibited greater sensitivity to nicotine's activity-increasing effects than did females initially exposed to nicotine in adulthood (i.e., Drug Phase II). (c) 2005 Elsevier Inc. All rights reserved.