A model for implantation of the human blastocyst and early placentation
A model for implantation of the human blastocyst and early placentation
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DOI：
10.1093/humupd/2.3.262
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发表时间：
1996-05-01
影响因子：
13.3
通讯作者：
Campana, A
中科院分区：
文献类型：
--
作者：
Bischof, P;Campana, A
我们在此描述了一个胚泡植入的分子模型，该模型基于两个假设：（i）人胚泡植入子宫内膜是一个与肿瘤侵入宿主组织非常相似的过程;以及（ii）早期妊娠的细胞滋养层细胞几乎保留了胚泡滋养外胚层细胞的所有特性，因此可以用作研究胚胎发育的替代物。体外植入过程。我们的模型认为，滋养外胚层细胞，一旦他们到达子宫内膜基底膜，表达整合素（α 6 β 4），锚他们进入基底膜，并诱导他们分泌明胶酶。这些蛋白酶消化基底膜，允许胚胎与子宫内膜细胞外基质（ECM）接触。整合素（α 5 β 1）将胚胎锚到ECM中并诱导其分泌胶原酶。这些酶消化ECM，使胚胎钻入子宫内膜。这一过程受子宫内膜细胞因子和ECM糖蛋白的旁分泌控制。
We describe here a molecular model of blastocyst implantation which is based on two assumptions: (i) that implantation of the human blastocyst into the endometrium is a process which is very similar to tumour invasion of a host tissue; and (ii) that the cytotrophoblastic cells of a first trimester pregnancy retain almost all the properties of the trophectodermal cells of the blastocyst and can thus be used as surrogates to study the implantation process irt vitro. Our model considers that the trophectodermal cells, once they reach the endometrial basement membrane, express integrins (alpha 6 beta 4) which anchor them into the basement membrane and induce their secretion of gelatinases. These proteases digest the basement membrane, allowing the embryo to make contact with the endometrial extracellular matrix (ECM), Integrins (alpha 5 beta 1) anchor the embryo into the ECM and induce its secretion of collagenases. These enzymes digest the ECM, allowing the embryo to burrow into the endometrium. This process is under the paracrine control of endometrial cytokines and ECM glycoproteins.