Evidence for cell-receptor activity in lymphocyte stimulation by staphylococcal enterotoxin.
Evidence for cell-receptor activity in lymphocyte stimulation by staphylococcal enterotoxin.
复制标题
葡萄球菌肠毒素刺激淋巴细胞时细胞受体活性的证据。
DOI：
10.4049/jimmunol.115.1.49
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发表时间：
1975
影响因子：
4.4
通讯作者：
J. Metzger
中科院分区：
文献类型：
--
作者：
J. Warren;D. L. Leatherman;J. Metzger
宽剂量反应曲线和特定抗毒素对有丝分裂的抑制作用表明，葡萄球菌肠毒素激活多克隆淋巴细胞需要毒素与对该蛋白具有低亲和力的淋巴细胞受体直接相互作用。葡萄球菌肠毒素 A、B 和 C1 具有同等的促有丝分裂活性。因此，参与肠毒素激活的淋巴细胞受体似乎对毒素分子的非抗原区域具有特异性。单糖（半抗原）抑制数据表明，葡萄球菌肠毒素的淋巴细胞受体缺乏α-甘露糖苷、半乳糖、乙酰半乳糖胺、乙酰葡糖胺和岩藻糖（或密切相关的糖）作为决定性糖，因此在结构上与凝集素细胞受体显着不同。
A wide dose-response curve and the inhibitory effect on mitogenicity of specific antitoxin suggest that polyclonal lymphocyte activation by staphylococcal enterotoxin requires direct interaction of toxin with lymphocyte receptors of low avidity for the protein. Staphylococcal enterotoxins A, B, and C1 demonstrated equivalent mitogenic activity. Lymphocyte receptors involved in enterotoxin activation thus appear to be specific for nonantigenic regions of the toxin molecule. Monosaccharide (hapten) inhibiton data indicate that lymphocyte receptors for staphylococcal enterotoxin lack alpha-mannoside, galactose, acetylgalactosamine, acetylglucosamine, and fucose (or closely related saccharides) as determinant sugars and thus differ significantly in structure from lectin cell receptors.