Filamentous growth is a general feature of Candida auris clinical isolates
Filamentous growth is a general feature of Candida auris clinical isolates
复制标题
DOI：
10.1093/mmy/myaa116
复制
发表时间：
2021-01-23
期刊：
影响因子：
2.9
通讯作者：
Du, Han
中科院分区：
文献类型：
--
作者：
Fan, Shuru;Yue, Huizhen;Du, Han
致病性念珠菌的一个显著特征是形态可塑性，有利于环境适应和宿主感染。耳念珠菌是一种新兴的多重耐药真菌病原体，于2009年在日本首次描述。在这项研究中，我们证明了临床分离的C。耳具有多种菌落和细胞形态，包括酵母、丝状、聚集和伸长形式。这种表型多样性已在8个临床分离的C。耳代表了四个主要的遗传分支，这表明它可能是一个普遍的特征。我们进一步证明了不同细胞类型的C。在Galleria mellonella感染模型中，auris表现出明显的抗真菌抗性和毒力特性。形态多样性是C.耳念珠菌（Candida auris）是一种新出现的多重耐药真菌病原体。形态学分析表明，趋化是临床分离的念珠菌的一个普遍特征。耳。这种能力与抗真菌药物的耐药性和毒力有关。
A striking feature of pathogenic Candida species is morphological plasticity that facilitates environmental adaptation and host infection. Candida auris is an emerging multidrug-resistant fungal pathogen first described in Japan in 2009. In this study, we demonstrate that clinical isolates of C. auris have multiple colony and cellular morphologies including the yeast, filamentous, aggregated, and elongated forms. This phenotypic diversity has been observed in eight clinical isolates of C. auris representing four major genetic clades, suggesting that it could be a general characteristic. We further demonstrate that different cell types of C. auris exhibit distinct antifungal resistance and virulence properties in a Galleria mellonella infection model. Our findings imply that morphological diversity is an important biological feature of C. auris and could be a contributor to its emergence and rapid prevalence worldwide.Lay SummaryCandida auris is an emerging multidrug-resistant fungal pathogen. Morphological analyses indicate that filamentation is a general feature of clinical isolates of C. auris. This ability is associated with antifungal resistance and virulence.