Spinal nerve injury increases the percentage of cold-responsive DRG neurons
Spinal nerve injury increases the percentage of cold-responsive DRG neurons
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DOI：
10.1097/00001756-200403010-00015
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发表时间：
2004-03-01
期刊：
影响因子：
1.7
通讯作者：
Gold, MS
中科院分区：
文献类型：
--
作者：
Djouhri, L;Wrigley, D;Gold, MS
我们测试了神经损伤后观察到的冷异常性疼痛反映感觉神经元冷反应性变化的假设。为了验证这一假设，我们评估了脊髓神经结扎（SNL）模型的神经损伤的皮肤感觉神经元的反应，在体外冷却的影响。神经损伤诱导未受伤但未受伤的神经节中冷反应皮肤神经元的发生率显著增加。因为在未受伤的神经节中冷反应神经元的百分比的增加应该增加总的神经元对外周组织冷却的反应，这些研究结果表明，冷异常性疼痛至少部分反映了感觉神经元的变化。
We tested the hypothesis that cold allodynia, observed following nerve injury reflects change(s) in the cold responsiveness of sensory neurons. To test this hypothesis we assessed the impact of the spinal nerve ligation (SNL) model of nerve injury on the responses of cutaneous sensory neurons to cooling in vitro. Nerve injury induced a significant increase in the incidence of cold responsive cutaneous neurons in uninjured but not injured ganglia. Because an increase in the percentage of cold responsive neurons in uninjured ganglia should increase the total neuronal response to cooling of peripheral tissue, these findings suggest that cold allodynia reflects, at least in part, a change in sensory neurons.