Long non-coding RNAs: potential molecular biomarkers for gliomas diagnosis and prognosis
Long non-coding RNAs: potential molecular biomarkers for gliomas diagnosis and prognosis
复制标题
长非编码RNA：神经胶质瘤诊断和预后的潜在分子生物标志物。
DOI：
10.1515/revneuro-2016-0066
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发表时间：
2017-06-01
影响因子：
4.1
通讯作者：
Xia, Ying
中科院分区：
文献类型：
--
作者：
Wang, Lei;Yu, Zhengtao;Xia, Ying
现行的胶质瘤分级系统是基于肿瘤的组织病理学特征，对于确定临床评估的患者群体具有重要意义。然而，这种分类系统也与一些限制相关，因此，需要额外的临床评估标准。长非编码RNA(Long Non-Coding RNAs，LncRNAs)在细胞功能中起着关键作用，目前被认为是脑胶质瘤诊断和预后的潜在生物标志物。因此，基于LncRNA表达的胶质瘤分子分类可能为胶质瘤的系统鉴定提供补充信息。在本文中，我们综述了最近的证据表明，特定的lncRNAs可能具有作为关键的新的生物标记物的潜力，从而为胶质瘤的系统诊断提供了强有力的工具。
The current grade classification system of gliomas is based on the histopathological features of these tumors and has great significance in defining groups of patients for clinical assessment. However, this classification system is also associated with a number of limitations, and as such, additional clinical assessment criteria are required. Long non-coding RNAs (lncRNAs) play a critical role in cellular functions and are currently regarded as potential biomarkers for glioma diagnosis and prognosis. Therefore, the molecular classification of glioma based on lncRNA expression may provide additional information to assist in the systematic identification of glioma. In the present paper, we review the emerging evidence indicating that specific lncRNAs may have the potential for use as key novel biomarkers and thus provide a powerful tool for the systematic diagnosis of glioma.