Rifins:: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
Rifins:: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
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DOI：
10.1073/pnas.96.16.9333
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发表时间：
1999-08-03
影响因子：
11.1
通讯作者：
Newbold, CI
中科院分区：
文献类型：
--
作者：
Kyes, SA;Rowe, JA;Newbold, CI
许多病原体通过表达表面蛋白来逃避宿主的免疫反应或适应环境。就恶性疟原虫而言，var多基因家族的产物在受感染的红细胞表面表达，在那里它们经历克隆性抗原变异，并通过介导与多种宿主内皮受体的粘附以及通过形成玫瑰花簇与未感染的红细胞的粘附，从而促进疟疾的发病机制。在这里，我们展示了第二个基因家族rif，它在基因组的亚端粒位点与var相关。它们的高拷贝数、序列变异性和红细胞表面位置表明，rifins在疟疾宿主-寄生虫相互作用中起着重要作用。
Many pathogens evade the host immune response or adapt to their environment by expressing surface proteins that undergo rapid switching. In the case of Plasmodium falciparum, products of a multigene family known as var are expressed on the surface of infected red cells, where they undergo clonal antigenic variation and contribute to malaria pathogenesis by mediating adhesion to a variety of host endothelial receptors and to uninfected red blood cells by forming rosettes, Herein we show that a second gene family, rif, which is associated with var at subtelomeric sites in the genome, encodes clonally variant proteins (rifins) that are expressed on the infected red cell surface, Their high copy number, sequence variability, and red cell surface location indicate an important role for rifins in malaria host-parasite interaction.