Apoptosis genes and autoimmunity.
Apoptosis genes and autoimmunity.
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DOI：
10.1016/s0952-7915(00)00168-0
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发表时间：
2000-12
影响因子：
7
通讯作者：
D. Vaux;R. Flavell
中科院分区：
文献类型：
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作者：
D. Vaux;R. Flavell
为了理解自身免疫，人们常常把注意力放在细胞死亡的过程上。毕竟，细胞凋亡是免疫细胞选择的过程，靶器官的细胞最终死亡，在一些自身免疫性疾病中发现了细胞死亡基因的突变。此外，当某些细胞死亡基因被删除时，一些自身免疫易感性小鼠不会发生疾病，而表达其他细胞死亡基因的转基因小鼠则会发生自身免疫。然而，只有一小部分人类自身免疫性疾病与个体基因突变有关，即使在这些罕见的情况下，遗传背景对疾病的严重程度也有重大影响。了解常见自身免疫性疾病的病理生理学需要阐明许多不同的系统，这些系统以复杂的方式相互作用，细胞凋亡过程只是其中之一。
To try to understand autoimmunity, attention has often fallen on the process of cell death. After all, apoptosis is used during selection of immunocytes, cells in the target organs end up dying and mutations to cell death genes have been found in some autoimmune diseases. Furthermore, some autoimmune-prone mice fail to develop disease when certain cell death genes are deleted, and transgenic mice expressing other cell death genes develop autoimmunity. However, only a tiny proportion of human autoimmune disease is associated with mutations to individual genes and even in these rare cases the genetic background has a major influence on the severity of disease. An understanding of the pathophysiology of common autoimmune diseases will require elucidation of many different systems that interact in complex ways, of which the process of apoptosis is just one.