The effect of age on vitamin E status, metabolism, and function -: Metabolism as assessed by labeled tocopherols
The effect of age on vitamin E status, metabolism, and function -: Metabolism as assessed by labeled tocopherols
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DOI：
10.1196/annals.1331.004
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Winklhofer-Roob, BM
中科院分区：
文献类型：
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作者：
Brigelius-Flohé, R;Roob, JM;Winklhofer-Roob, BM
年龄对维生素E代谢的影响进行了研究，在97名健康的20-75岁的男性不吸烟的奥地利志愿者的VITAGE项目。单次口服30 mg d（6）-RRR-alpha-和d（2）-RRR-gamma-生育酚乙酸酯后，采集血液和24小时尿液。通过GC-MS分析血浆中的氘代生育酚和氘代尿代谢物。第一次评价显示，在前6小时内，d（6）-α-和d（2）-γ-生育酚的摄取相似，然后d（2）-γ-生育酚开始减少。尿中d（2）-γ-羧乙基羟基苯并二氢吡喃代谢物（CEHC）超过d（6）-α-CEHC约10倍。没有年龄的影响。因此，健康的老年非吸烟男性可能不需要更高的维生素E摄入量。
The effects of age on vitamin E metabolism were studied in 97 healthy 20-75-year-old male nonsmoking Austrian volunteers of the VITAGE project. After a single oral intake of 30 mg d(6)-RRR-alpha- and d(2)-RRR-gamma-toco-pheryl acetate, blood and 24-hour urine was collected. Deuterated tocopherols in plasma and deuterated urinary metabolites were analyzed by GC-MS. A first evaluation revealed a similar uptake of d(6)-alpha- and d(2)-gamma-tocopherol during the first 6 hours, and then d(2)-gamma-tocopherol started to decrease. Urinary d(2)-gamma-carboxyethyl hydroxychroman metabolites (CEHCs) exceeded those of d(6)-alpha-CEHCs by about 10 times. There was no effect of age. Thus, there might be no need for a higher vitamin E intake for healthy elderly nonsmoking men.