A specific deficit of dorsal stream function in Williams' syndrome
A specific deficit of dorsal stream function in Williams' syndrome
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DOI：
10.1097/00001756-199705260-00025
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发表时间：
1997-05-27
期刊：
影响因子：
1.7
通讯作者：
Braddick, F
中科院分区：
文献类型：
--
作者：
Atkinson, J;King, J;Braddick, F
威廉姆斯综合征（WS）是一种罕见的，基于遗传的认知发育障碍。受影响的个体表现出严重的空间认知缺陷，但语言和面部识别相对较少。为了研究可能的神经基础的空间缺陷，我们测试了一组WS儿童，年龄在4-14岁，在两个措施具体到背侧皮质流功能：全球运动相干阈值，在比较类似的形式一致性测试，和视觉手动准确性张贴卡通过插槽，相比匹配的插槽方向。这些任务的缺陷提供了第一个证据，具体参与WS的背流，皮质系统被认为是编码信息的空间关系和视觉控制的行动。
WILLIAMS' syndrome (WS) is a rare, genetically based disorder of cognitive development. Affected individuals show a severe deficit of spatial cognition but a relative sparing of language and face recognition. To examine the possible neural basis of the spatial deficit, we tested a group of WS children, aged 4-14 years, on two measures specific to dorsal cortical stream function: global motion coherence thresholds, in comparison with an analogous form-coherence test, and visuo-manual accuracy in posting a card through a slot, compared with matching the slot orientation. Deficits in these tasks provide the first evidence of specific involvement in WS of the dorsal stream, the cortical system believed to encode information about spatial relationships and the visual control of action.