Homeostatic competition drives tumor growth and metastasis nucleation
Homeostatic competition drives tumor growth and metastasis nucleation
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DOI：
10.2976/1.3086732
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发表时间：
2009-08-01
期刊：
影响因子：
--
通讯作者：
Prost, Jacques
中科院分区：
文献类型：
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作者：
Basan, Markus;Risler, Thomas;Prost, Jacques
我们提出了一种肿瘤生长的机制，强调了稳态调节和组织稳定性的作用。我们表明，表面和体积效应之间的竞争导致存在一个临界尺寸，必须克服转移，以达到宏观尺寸。这种性质可以定性地解释所观察到的转移瘤的大小分布，而大小无关的生长率不能解释临床和实验数据。此外，它可能解释了观察到的转移瘤在组织表面和膜（如胸膜和腹膜层）上的优先生长，表明了Stephen佩吉特在1889年引入的种子和土壤假说的机制，并产生了转移性低效率的现实值。我们提出了一些关键的实验来测试这些概念。在这项工作中引入的稳态压力可以构成一个定量的，实验上可获得的早期恶性肿瘤的转移潜力的措施。[DOI：10.2976/1.3086732]
We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk effects leads to the existence of a critical size that must be overcome by metastases to reach macroscopic sizes. This property can qualitatively explain the observed size distributions of metastases, while size-independent growth rates cannot account for clinical and experimental data. In addition, it potentially explains the observed preferential growth of metastases on tissue surfaces and membranes such as the pleural and peritoneal layers, suggests a mechanism underlying the seed and soil hypothesis introduced by Stephen Paget in 1889, and yields realistic values for metastatic inefficiency. We propose a number of key experiments to test these concepts. The homeostatic pressure as introduced in this work could constitute a quantitative, experimentally accessible measure for the metastatic potential of early malignant growths. [DOI: 10.2976/1.3086732]